{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T16:23:36Z","timestamp":1789662216047,"version":"4.0.1"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T00:00:00Z","timestamp":1719187200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Domestic Animals"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Evaluation of the metabolic profile indices allows early detection and treatment of various metabolic disorders during the transition period in ewes. This study aimed to determine the variations in the blood metabolites around lambing in Ossimi ewes. The blood metabolites were investigated in ewes with single (<jats:italic>n<\/jats:italic>\u2009=\u200927) and multiple (<jats:italic>n<\/jats:italic>\u2009=\u20099) lambs at 3\u2010 and 1\u2010week pre\u2010lambing and 3\u2010week post\u2010lambing. The plasma concentrations of glucose were higher in single\u2010bearing ewes than those in multiple\u2010bearing ewes (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05), moreover, its lowest value was measured at 1\u2010week prepartum in both groups. Throughout the study period, the serum concentrations of non\u2010esterified fatty acids (NEFA) were significantly increased in ewes with multiple lambs compared to ewes with single lambs (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05), and the highest value was found at 1\u2010week before parturition in both groups. In addition, the serum level of beta\u2010hydroxybutyric acid (BHBA) was higher at 3\u2010week postpartum, and it was significantly increased in multiple\u2010bearing ewes than that in single\u2010bearing ones (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05) at 3\u2010week pre\u2010lambing. In both groups, the lowest values of total proteins were determined 1\u2010week before lambing, and its concentrations, at 3\u2010 and 1\u2010week prepartum, were higher in ewes with single lambs than those with multiple lambs (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). In contrast, the serum concentrations of albumin were significantly lowered 1\u2010week postpartum (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05), and without significant differences between both groups (<jats:italic>p<\/jats:italic>\u2009&gt;\u2009.05). The serum activities of aspartate aminotransferase (AST) and gamma\u2010glutamyltransferase (GGT) were significantly increased at 1\u2010week after parturition in both groups (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). Furthermore, the serum activities of AST were higher in multiple\u2010bearing ewes than those in single\u2010bearing ones at 3\u2010week pre\u2010lambing and 3\u2010week post\u2010lambing (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). Variable positive and negative correlations were determined among the blood metabolites. In conclusion, physiological adaptations are associated with the fluctuation of the blood metabolites around lambing. The higher the number of foetuses the higher the metabolic variations in Ossimi ewes. Therefore, regular metabolic profiling for health monitoring may be necessary to avoid disease development during the transition period.<\/jats:p>","DOI":"10.1111\/rda.14649","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T07:30:14Z","timestamp":1719214214000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Variations of blood metabolites in single\u2010 and multiple\u2010bearing Ossimi ewes during the transition period"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0449-8283","authenticated-orcid":false,"given":"Hussein Awad","family":"Hussein","sequence":"first","affiliation":[{"name":"Veterinary Internal Medicine, Department of Animal Medicine, Faculty of Veterinary Medicine Assiut University  Assiut Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amany M.","family":"Mohammed\u00a0Omer","sequence":"additional","affiliation":[{"name":"A Field Veterinarian Directorate of Veterinary Medicine  Sohag Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad H.","family":"Karam","sequence":"additional","affiliation":[{"name":"Veterinary Internal Medicine, Department of Animal Medicine, Faculty of Veterinary Medicine Assiut University  Assiut Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.21608\/jappmu.2023.206649.1073"},{"key":"e_1_2_11_3_1","first-page":"275","article-title":"Some biochemical constituents in the blood serum of pregnant Awassi ewes","volume":"12","author":"Al\u2010Dewachi O. 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