{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:45:20Z","timestamp":1753879520985,"version":"3.41.2"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T00:00:00Z","timestamp":1724198400000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Domestic Animals"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The reproductive efficiency in buffalo is highly influenced by seasonal variability. Angiogenesis in the reproductive cycle is important for optimal physiological functioning of uterus. Estrogen receptor\u2010\u03b1 (ER\u03b1), vascular endothelial growth factor (VEGF) and reduced nicotinamide adenine dinucleotide phosphatase diaphorase (NADPH\u2010d) are vital indicators for the uterine angiogenic process. This study was conducted to see the effect of season on the expression of different uterine angiogenic factors. Season wise (winter and summer) and phase wise (follicular and luteal), immune staining intensity of buffalo uterus was measured by calculating the optical density value (OD) for ER\u03b1 and VEGF. Percentage of immuno\u2010positive cell count for ER\u03b1 was done. Histoenzymic NADPH\u2010d expression was analysed. Expression of all these factors increased during follicular phase of oestrous cycle in order to support the angiogenesis; however, the expression was significantly lower (<jats:italic>p<\/jats:italic>\u2009\u2264\u20090.05) in term of OD value as well as percentage count of immuno\u2010positive cells during summer season indicating lower angiogenic activity that subsequently affected reproduction in buffalo.<\/jats:p>","DOI":"10.1111\/rda.14710","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T05:54:27Z","timestamp":1724306067000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the Nexus of Steroidal Hormone Receptor, Uterine <scp>VEGF<\/scp> Expression and <scp>NADPH<\/scp>\u2010d Interaction in Buffalo Uterus During Oestrous Cycle With Seasonal Variation"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4962-4951","authenticated-orcid":false,"given":"Sagarika","family":"Dehury","sequence":"first","affiliation":[{"name":"Department of Veterinary Anatomy Guru Angad Dev Veterinary and Animal Science University  Ludhiana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Varinder","family":"Uppal","sequence":"additional","affiliation":[{"name":"Department of Veterinary Anatomy Guru Angad Dev Veterinary and Animal Science University  Ludhiana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devendra","family":"Pathak","sequence":"additional","affiliation":[{"name":"Department of Veterinary Anatomy Guru Angad Dev Veterinary and Animal Science University  Ludhiana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anuradha","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Veterinary Anatomy Guru Angad Dev Veterinary and Animal Science University  Ludhiana India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441\u2010005\u20101085\u20109"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1023\/a:1009292506879"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000014928.45119.73"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.14202\/vetworld.2016.235\u2010244"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523\u20101755.2005.00575.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.18.1.0287"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr304"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2019.04.021"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.1.06184"},{"issue":"11","key":"e_1_2_9_11_1","first-page":"1440","article-title":"Immunohistochemical Detection of Alpha\u2010Smooth Muscle Actin and S\u2010100 in Bovine Mammary Gland With Mastitis","volume":"53","author":"Leishangthem G. 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