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It is expressed in various tumour tissues, with its expression level closely associated with tumour invasion, metastasis and prognosis. Recent studies utilising proteomic analysis and other methods have highlighted the noteworthy expression of the TKTL1 gene in germ cells, particularly in spermatogonia and ovarian cells. Consequently, this article reviews the molecular characteristics of TKTL1 and its expression in germ cells to provide a reference for research on TKTL1 beyond tumour cells.<\/jats:p>","DOI":"10.1111\/rda.14723","type":"journal-article","created":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T13:16:47Z","timestamp":1727097407000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Molecular Characteristics and Expression of <scp>TKTL1<\/scp> in Germ Cells: Implications for Nontumour Cell Research"],"prefix":"10.1111","volume":"59","author":[{"given":"Xiaole","family":"Yuan","sequence":"first","affiliation":[{"name":"Shaanxi Province Engineering &amp; Technology Research Center of Cashmere Goat Yulin University  Yulin Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huaiyan","family":"Kang","sequence":"additional","affiliation":[{"name":"Animal Disease Prevention and Control Center of Zizhou County  Zizhou Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Liu","sequence":"additional","affiliation":[{"name":"Shaanxi Province Engineering &amp; Technology Research Center of Cashmere Goat Yulin University  Yulin Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuwei","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Histo\u2010Embryology, Genetics and Developmental Biology, Shanghai Key Laboratory of Reproductive Medicine Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haijing","family":"Zhu","sequence":"additional","affiliation":[{"name":"Shaanxi Province Engineering &amp; Technology Research Center of Cashmere Goat Yulin University  Yulin Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shenghui","family":"Chen","sequence":"additional","affiliation":[{"name":"Shaanxi Province \"Four Subjects One Union\" Sheep and Goat Engineering &amp; Technology University &amp; Enterprise Alliance Research Center  Shenmu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomin","family":"Du","sequence":"additional","affiliation":[{"name":"Shaanxi Province Engineering &amp; Technology Research Center of Cashmere Goat Yulin University  Yulin Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymben.2016.05.005"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23073574"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1996.0124"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11061026"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2018.06.010"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2022.104686"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12900-018-0099-y"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.10429"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.107.074823"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0082087"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113607"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.23656"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19082168"},{"key":"e_1_2_11_15_1","unstructured":"Huang F. 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