{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T18:24:37Z","timestamp":1789064677043,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T00:00:00Z","timestamp":1729900800000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Domestic Animals"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>This preliminary study evaluated the biocompatibility of a novel degradable intravaginal plug contraceptive composed of PEG 4000 and chitosan in cats using haematological profiling and vaginal cytology. Five healthy, non\u2010pregnant female cats were fully anaesthetised and fitted with an intravaginal plug (10\u2009\u00d7\u20090.3\u2009mm) using an applicator, following oestrogen administration 3\u2009h prior. Blood samples were collected from the cephalic vein on days 0 (pre\u2010insertion) and 3 and 7 (post\u2010insertion). Vaginal cytology examinations were conducted on day 0 (pre\u2010 and post\u2010oestrogen injection) and days 1, 3 and 7 post\u2010insertion. Haematological parameters, including red blood cell count, haemoglobin levels, haematocrit values, total white blood cell count and differentiation, showed no significant changes after contraceptive insertion (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). Vaginal cytology indicated an acute inflammatory response in one out of five subjects on day three post\u2010insertion. The distribution of vaginal epithelial cells (parabasal, intermediate and superficial) remained unaffected by contraception. Oestrogen injection resulted in the dominance of superficial cells up to day 7 of observation (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Overall, PEG 4000 and chitosan\u2010based intravaginal plug contraceptives demonstrated sufficient biocompatibility, indicating their potential as viable contraceptive options for feline use.<\/jats:p>","DOI":"10.1111\/rda.14736","type":"journal-article","created":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T13:10:37Z","timestamp":1729948237000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Novel Intravaginal Contraceptive Plug for Cats: A Preliminary Biocompatibility Assessment on Haematology and Vaginal Swab"],"prefix":"10.1111","volume":"59","author":[{"given":"Sella\u00a0Sofia","family":"Ainun","sequence":"first","affiliation":[{"name":"Program of Veterinary Medicine, School of Veterinary Medicine and Biomedical Sciences IPB University, Jalan Agathis, Kampus IPB Dramaga  Bogor West Java Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad\u00a0Irham\u00a0Bagus","family":"Santoso","sequence":"additional","affiliation":[{"name":"Program of Veterinary Medicine, School of Veterinary Medicine and Biomedical Sciences IPB University, Jalan Agathis, Kampus IPB Dramaga  Bogor West Java Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2802-7841","authenticated-orcid":false,"given":"Elma\u00a0Yuliani","family":"Yessa","sequence":"additional","affiliation":[{"name":"Postgraduate Program of Biology Reproduction, School of Veterinary Medicine and Biomedical Sciences IPB University, Jalan Agathis, Kampus IPB Dramaga  Bogor West Java Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7208-7040","authenticated-orcid":false,"family":"Gunanti","sequence":"additional","affiliation":[{"name":"Division of Surgery and Radiology, School of Veterinary Medicine and Biomedical Sciences IPB University, Jalan Agathis, Kampus IPB Dramaga  Bogor West Java Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6054-3862","authenticated-orcid":false,"given":"Ahmad\u00a0Kafrawi","family":"Nasution","sequence":"additional","affiliation":[{"name":"Biomaterials Technology Laboratory (BTL), Department of Mechanical Engineering, Faculty of Engineering Universitas Muhammadiyah Riau  Pekanbaru Riau Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5114-3453","authenticated-orcid":false,"given":"Syafiqah","family":"Saidin","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Health Sciences, Faculty of Electrical Engineering Universiti Teknologi Malaysia  Johor Bahru Johor Malaysia"},{"name":"IJN\u2010UTM Cardiovascular Engineering Centre, Institute of Human Centered Engineering Universiti Teknologi Malaysia  Johor Bahru Johor Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2092-9645","authenticated-orcid":false,"given":"Mokhamad\u00a0Fakhrul","family":"Ulum","sequence":"additional","affiliation":[{"name":"Division of Reproduction, Obstetrics and Gynaecology, School of Veterinary Medicine and Biomedical Sciences IPB University, Jalan Agathis, Kampus IPB Dramaga  Bogor West Java Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.33393\/dti.2023.2477"},{"issue":"9","key":"e_1_2_10_3_1","first-page":"2053","article-title":"Leukocytosis: Basics of Clinical Assessment","volume":"62","author":"Abramson N.","year":"2000","journal-title":"American Family Physician"},{"key":"e_1_2_10_4_1","volume-title":"Tumbuhan Dengan Kandungan Senyawa Aktif Yang Berpotensi Sebagai Bahan Antifertilisasi","author":"Akbar B.","year":"2010"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478\u20103231.2011.02639.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.18433\/J3HP41"},{"key":"e_1_2_10_7_1","unstructured":"Berutu S. 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