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To achieve the target of livestock production, the availability of superior male germplasm is a great concern. In developing countries, there is a gap between the highly fertile frozen semen doses produced and the highly fertile frozen semen doses required. Improving the quality of existing low\u2010fertile semen from high genetic merit bulls seems to play a promising role in filling this gap. Seminal exosomes are extracellular vesicles secreted by the epithelial cells of the testis, epididymis, and accessory sex glands such as the prostate gland. They contain a cargo of bioactive molecules such as proteins, nucleic acids and various metabolites. These molecules are transferred to the spermatozoa during its maturation and help in sperm capacitation, maturation, acrosome reaction, and fertilisation. Studies reveal that seminal exosomes help to improve the sperm functionality of low\u2010quality sperm. Identification of the molecular profile of exosomes of bulls with proven fertility and their addition in an extender containing low\u2010fertile semen may help to ameliorate the sperm quality of low\u2010fertile semen, which may eventually aid in generating quantities of highly fertile ejaculates.<\/jats:p>","DOI":"10.1111\/rda.70000","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T14:10:02Z","timestamp":1734963002000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Understanding the Crucial Role of Seminal Plasma Exosomes in Bull Fertility: A Review"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2699-7729","authenticated-orcid":false,"given":"Manisha","family":"Sethi","sequence":"first","affiliation":[{"name":"Animal Reproduction, Gynaecology and Obstetrics Artificial Breeding Research Centre (ABRC), ICAR\u2010National Dairy Research 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