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The effect of SRI treatment on canine testicular function is well characterised, although the effect of downregulation and subsequent recovery on epididymal function has not been studied yet. Therefore, twenty\u2010nine healthy male dogs were treated with a 4.7\u2009mg SRI for five months. Subsequent to implant removal, groups of 4\u20135 dogs were surgically castrated either at implant removal (week 0) or 2, 4, 6, or 10\u2009weeks later. Three subgroups were categorised according to pre\u2010surgical testosterone levels. Five healthy untreated dogs served as control. Epididymides were separated into head, body and tail. Epididymal duct diameter and epithelial height were measured using haematoxylin\u2013eosin\u2010stained sections of each dog and part of epididymides. Besides, the presence of spermatozoa, the cilial height, the thickness of the muscle layers and the relative amount of connective tissue were semiquantitatively assessed. The downregulated epididymis was characterised by a reduced epithelial height and epididymal duct diameter, lower cilia and absence of sperm, but more connective tissue, supporting that epididymal function is significantly altered by SRI treatment. At recovery subsequent to implant removal, the histomorphology was comparable with untreated controls. The study indicates that recovery of the epididymal function, like spermatogenesis, depends on testicular testosterone production.<\/jats:p>","DOI":"10.1111\/rda.70013","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T10:09:39Z","timestamp":1739354979000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Histomorphological Changes in the Canine Epididymis During Downregulation and Recovery After Deslorelin Treatment"],"prefix":"10.1111","volume":"60","author":[{"given":"Henriette","family":"Greiner","sequence":"first","affiliation":[{"name":"Unit for Reproductive Medicine\u2014Clinic for Small Animals University of Veterinary Medicine Hannover, Foundation  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"K\u00f6rber","sequence":"additional","affiliation":[{"name":"Unit for Reproductive Medicine\u2014Clinic for Small Animals University of Veterinary Medicine Hannover, Foundation  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva\u2010Maria","family":"Packeiser","sequence":"additional","affiliation":[{"name":"Unit for Reproductive Medicine\u2014Clinic for Small Animals University of Veterinary Medicine Hannover, Foundation  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines","family":"Focks","sequence":"additional","affiliation":[{"name":"Unit for Reproductive Medicine\u2014Clinic for Small Animals University of Veterinary Medicine Hannover, Foundation  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selim","family":"Aslan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Faculty of Veterinary Medicine Near East University  Nicosia Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serhan","family":"Ay","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Faculty of Veterinary Medicine Ondokuz May\u0131s University  Samsun Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Findik","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Faculty of Veterinary Medicine Ondokuz May\u0131s University  Samsun Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcl\u015fah","family":"Saral","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Faculty of Veterinary Medicine Ondokuz May\u0131s University  Samsun Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eser","family":"Akal","sequence":"additional","affiliation":[{"name":"Department of Reproduction and Artificial Insemination, Faculty of Veterinary Medicine Ondokuz May\u0131s University  Samsun Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christelle","family":"Fontaine","sequence":"additional","affiliation":[{"name":"Global Marketing and Market Development Virbac Group  Carros France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4327-9780","authenticated-orcid":false,"given":"Sandra","family":"Goericke\u2010Pesch","sequence":"additional","affiliation":[{"name":"Unit for Reproductive Medicine\u2014Clinic for Small Animals University of Veterinary Medicine Hannover, Foundation  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani11102961"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441\u2010012\u20101381\u20100"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prevetmed.2019.104730"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098\u20102795(200006)56:2<180::AID\u2010MRD9>3.0.CO;2\u20104"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmn055"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0730405"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.1196"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1530\/rep\u201017\u20100754"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/rda.12898"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439\u20100531.2011.01933.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439\u20100531.2009.01378.x"},{"key":"e_1_2_9_13_1","first-page":"563","article-title":"Hormonelle Downregulation der Hodenfunktion bei R\u00fcde und Kater; 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