{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T06:10:09Z","timestamp":1756188609256,"version":"3.44.0"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T00:00:00Z","timestamp":1741219200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32460836"],"award-info":[{"award-number":["32460836"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Domestic Animals"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Rapid uterus involution is essential for minimising interpartum intervals, enhancing reproductive performance, and optimising production in ewes. This study aimed to accelerate the uterine involution of postpartum ewes through a relatively simple hormone treatment approach. In this study, 96 Dorper\u2009\u00d7\u2009Hu F1 ewes were assigned to three groups. The ewes were subsequently injected with normal saline (control group), prostaglandin + oxytocin (PG\u2009+\u2009OT group) and prostaglandin + oxytocin + horse chorionic gonadotropin (PG\u2009+\u2009OT\u2009+\u2009eCG group). Each group had 16 ewes producing a single lamb and 16 ewes producing twin lambs used to determine the effects of different treatments on their uterine involution and reproductive performance. PG\u2009+\u2009OT\u2009+\u2009eCG treatment accelerated the rate of uterine horn involution of single lambs (21.40\u2009\u00b1\u20090.89\u2009days vs. 30.66\u2009\u00b1\u20091.03\u2009days, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) and twin hlambs (22.2\u2009\u00b1\u20091.09\u2009days vs. 30.33\u2009\u00b1\u20090.81\u2009days, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) compared to the control group. PG\u2009+\u2009OT\u2009+\u2009eCG treatment also accelerated the regression of the uterine wall serosa structure and the removal of uterine effusion compared to PG\u2009+\u2009OT treatment, whose effect was moderate. PG\u2009+\u2009OT and PG\u2009+\u2009OT\u2009+\u2009eCG treatments had no significant effect on the recovery of the maximum uterine diameter of single and double lambing ewes compared to the control group. However, both treatments shortened the first estrus time of postpartum ewes (53.73\u2009\u00b1\u20093.69\u2009days vs. 48.06\u2009\u00b1\u20095.87\u2009days vs. 46.46\u2009\u00b1\u20097.41\u2009days, <jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). There was no significant difference in the conception rate among groups (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). Notably, the change trend of reproductive hormones in postpartum ewes was consistent. PG\u2009+\u2009OT and PG\u2009+\u2009OT\u2009+\u2009eCG treatments significantly increased the concentration of estradiol and follicle\u2010stimulating hormone during uterine involution (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), but inhibited the secretion of progesterone compared to the control group. The peak of the luteinising hormone in the two treatment groups appeared 14\u2009days earlier compared to that of the control group. In summary, exogenous PG\u2009+\u2009OT\u2009+\u2009eCG increases the concentration of estradiol during uterine involution, inhibits the secretion of progesterone, and accelerates the postpartum uterine involution and postpartum estrus time of ewes. These findings provide a basis for exploring the mechanism of uterine involution in sheep and improving sheep production efficiency.<\/jats:p>","DOI":"10.1111\/rda.70044","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T18:37:54Z","timestamp":1741718274000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Enhanced Uterine Involution on Reproductive Performance in Multiparous Ewes"],"prefix":"10.1111","volume":"60","author":[{"given":"Dongliang","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology Shihezi University  Shihezi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1215-4509","authenticated-orcid":false,"given":"Chenlong","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Shihezi University  Shihezi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Zhu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Shihezi University  Shihezi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Tao","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Shihezi University  Shihezi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Shihezi University  Shihezi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Li","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Shihezi University  Shihezi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongli","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Shihezi University  Shihezi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangdong","family":"Hu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Shihezi University  Shihezi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanping","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Shihezi University  Shihezi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weibin","family":"Zeng","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Shihezi University  Shihezi China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.33899\/ijvs.2022.133212.2190"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.5455\/javar.2014.a10"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439\u20100531.2011.01830.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.165.21.623"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2018.09.022"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.22456\/1679\u20109216.105041"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/rda.122685"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbe.2022.12.004"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.16303\/j.cnki.1005\u20104545.2020.11.29"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.12000"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2006\u20100112"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.30539\/iraqijvm.v40i1.153"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2020.106460"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022\u20100302(97)76024\u20107"},{"key":"e_1_2_9_16_1","unstructured":"Liu Z.2022.\u201cThe Effects of Different Lambing Numbers and Drugs on the Postpartum Recovery of the Uterus in Primiparous Lake Sheep.\u201dMaster's Thesis (M.S. 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