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As a result, veterinarians often advocate for strategies such as postponing estrus in females to balance reproductive health and manage population control. In recent decades, advancements in pharmacological interventions have opened new doors. GnRH agonists, which can reversibly suppress reproductive function, have emerged as a safer and more flexible alternative to surgical sterilisation. Similarly, the use of melatonin in female cats has shown promising results in regulating estrus cycles. Other innovative solutions, such as non\u2010surgical sterilisation techniques using immunocontraceptive vaccines, are under active development, offering hope for scalable, humane population control measures. These emerging technologies provide veterinarians with an expanding toolkit to address both clinical and ethical challenges in reproductive management.<\/jats:p>","DOI":"10.1111\/rda.70107","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T08:19:58Z","timestamp":1756887598000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Advancing and Historical Reversible Contraceptive Solutions for Feline Reproductive Control"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4994-768X","authenticated-orcid":false,"given":"Lluis Ferr\u00e9","family":"Dolcet","sequence":"first","affiliation":[{"name":"Private Practitioner  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,3]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2012.03.030"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2018.02.014"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.THERIOGENOLOGY.2024.10.021"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0034\u20105288(96)90039\u20109"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.11606\/S1413-95962009000600005"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1439\u20100531.2006.00817.X"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2008.08.002"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091\u20100279(77)50080\u20109"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0195\u20105616(82)50007\u20101"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X16688406"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0034\u20105288(94)90101\u20105"},{"key":"e_1_2_15_13_1","first-page":"53","article-title":"Progestational Agents in Pet Practice, Indications, Agents and Doses","author":"Colton M.","year":"1965","journal-title":"Modern Veterinary Practice"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1983.182.06.621"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.THERIOGENOLOGY.2011.01.015"},{"key":"e_1_2_15_16_1","volume-title":"Canine and Feline Endocrinology: Fourth Edition","author":"Feldman E. 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