{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T13:29:39Z","timestamp":1765200579755,"version":"3.46.0"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:00:00Z","timestamp":1760572800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["88887.635440\/2021\u201000"],"award-info":[{"award-number":["88887.635440\/2021\u201000"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003046","name":"Empresa Brasileira de Pesquisa Agropecu\u00e1ria","doi-asserted-by":"publisher","award":["303727\/2021\u20107","4039092021\u20100"],"award-info":[{"award-number":["303727\/2021\u20107","4039092021\u20100"]}],"id":[{"id":"10.13039\/501100003046","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Domestic Animals"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study aimed to evaluate the effects of human chorionic gonadotropin (hCG) on the second prostaglandin F2\u03b1 (PGF2\u03b1) injection in anestrous Saanen goats that had been previously exposed to a 16\u2010h photoperiod. Seventy\u2010two pluriparous goats were subjected to a 16\u2010h photoperiod for 60\u2009days. Ten days later, synchronisation of estrus was conducted with two injections of cloprostenol administered 11.5\u2009days apart. At the second injection, goats received either 300\u2009IU of hCG (hCG group) or no hCG (control group). Estrus response, ovarian structures, progesterone (P4) concentrations, and pregnancy rates were assessed. Estrus response after the second cloprostenol injection (70.8%; 51\/72) was higher (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) than that of the first injection (39.0%; 28\/72;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Goats in the hCG group ovulated earlier (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05; 45.0\u2009\u00b1\u20095.9\u2009h) compared with the control (72.9\u2009\u00b1\u20094.8\u2009h), with a shorter interval between estrus and ovulation (\u22121.2\u2009\u00b1\u20097\u2009h vs. 34.2\u2009\u00b1\u20093.3\u2009h;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Although hCG increased the luteal area and P4 concentrations, pregnancy rate was drastically reduced (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.05) in the hCG group (25.0% vs. 47.2%). Moreover, hCG reduced (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) the incidence of premature luteal regression (11.1% vs. 30.6%). No differences were observed in follicular number or diameter between groups. It was concluded that even though hCG effectively induced ovulation and enhanced luteal function in goats during anestrus, its administration in conjunction with the second PGF2\u03b1 injection may have excessively advanced ovulation, impairing estrus\u2013ovulation synchrony, which markedly reduces pregnancy rate. Timings of hCG administration should be further explored to optimise its reproductive benefits without compromising pregnancy outcome.\n                  <\/jats:p>","DOI":"10.1111\/rda.70134","type":"journal-article","created":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T13:10:34Z","timestamp":1760620234000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of hCG Administration at the Second Cloprostenol Injection on the Reproductive Performance of Saanen Goats Previously Exposed to 16\u2010h Photoperiod"],"prefix":"10.1111","volume":"60","author":[{"given":"Paulo Sergio C.","family":"Rangel","sequence":"first","affiliation":[{"name":"Departamento de Medicina Veterin\u00e1ria Universidade Federal de Vi\u00e7osa  Vi\u00e7osa MG Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana N. D.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Universidade Federal Rural da Amaz\u00f4nia  Paragominas PA Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel B.","family":"Vergani","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista  S\u00e3o Paulo SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruna W.","family":"Freitas","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Veterin\u00e1ria Universidade Federal de Vi\u00e7osa  Vi\u00e7osa MG Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4027-5562","authenticated-orcid":false,"given":"Felipe Z.","family":"Brand\u00e3o","sequence":"additional","affiliation":[{"name":"Faculdade de Veterin\u00e1ria Universidade Federal Fluminense  Niter\u00f3i RJ Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4872-1718","authenticated-orcid":false,"given":"Joanna M. G.","family":"Souza\u2010Fabjan","sequence":"additional","affiliation":[{"name":"Faculdade de Veterin\u00e1ria Universidade Federal Fluminense  Niter\u00f3i RJ Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8028-3984","authenticated-orcid":false,"given":"Jeferson F.","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Embrapa Caprinos e Ovinos  Coronel Pacheco MG Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.ANIREPROSCI.2012.01.011"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.THERIOGENOLOGY.2018.12.035"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11250\u2010018\u20101696\u20102"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2019.106172"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP\u201013\u20100400"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1751731107691873"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477\u20107827\u20108\u2010102"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-800749-5.00011-0"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.domaniend.2020.106579"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2018.08.007"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1590\/1678\u20104162\u20109679"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0102\u201009352013000600001"},{"volume-title":"Programa de Melhoramento Gen\u00e9tico de Caprinos Leiteiros\u2014Capragene, 3\u00b0 Sum\u00e1rio de Avalia\u00e7\u00e3o Gen\u00e9tica, 2\u00b0 Sum\u00e1rio de Avalia\u00e7\u00e3o Gen\u00e9tica Gen\u00f4mica, Ano 2020 \u2013 Ra\u00e7a Saanen","year":"2020","author":"Faco O.","key":"e_1_2_10_14_1"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod38.2.413"},{"issue":"1","key":"e_1_2_10_16_1","first-page":"54","article-title":"Progesterone Profile and Reproductive Performance of Estrous\u2010Induced Alpine Goats Given hCG Five Days After Breeding","volume":"2","author":"Fonseca J. 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