{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T18:41:10Z","timestamp":1788374470218,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100018927","name":"Southwest Minzu University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018927","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Domestic Animals"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Cattleyak is a hybrid between cattle and yak; the underlying mechanism for its spermatogenic arrest is still unclear, and it's a typical male sterile mammal. In this work, we cloned the\n                    <jats:italic>OTUD6A<\/jats:italic>\n                    gene of cattleyak and analyzed it by bioinformatics. The expression level of\n                    <jats:italic>OTUD6A<\/jats:italic>\n                    in testicular tissues and undifferentiated spermatogonia of cattleyak was significantly lower than that in yak (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Overexpression of\n                    <jats:italic>OTUD6A<\/jats:italic>\n                    in cattleyak promoted the viability and proliferation activity of cattleyak undifferentiated spermatogonia (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Furthermore,\n                    <jats:italic>OTUD6A<\/jats:italic>\n                    overexpression resulted in significant upregulation of genes associated with proliferation (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Therefore, the aberrant expression of\n                    <jats:italic>OTUD6A<\/jats:italic>\n                    in undifferentiated spermatogonia of cattleyak impaired its proliferation and decreased its growth potentiality, thereby affecting the development of undifferentiated spermatogonia. This study provided a new theoretical basis for further elucidation of the molecular mechanism of spermatogenesis arrest in cattleyak.\n                  <\/jats:p>","DOI":"10.1111\/rda.70136","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T07:22:13Z","timestamp":1761117733000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Reduced\n                    <i>OTUD6A<\/i>\n                    Impairs Spermatogonia Proliferation and Contributes to Spermatogenic Arrest in Cattleyak"],"prefix":"10.1111","volume":"60","author":[{"given":"Wenjing","family":"Dong","sequence":"first","affiliation":[{"name":"Key Laboratory of Qinghai\u2010Tibetan Plateau Animal Genetic Resource Reservation and Utilization of Sichuan Province and Ministry of Education Southwest Minzu University  Chengdu Sichuan China"},{"name":"Key Laboratory for Animal Science of National Ethnic Affairs Commission Southwest Minzu University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Qinghai\u2010Tibetan Plateau Animal Genetic Resource Reservation and Utilization of Sichuan Province and Ministry of Education Southwest Minzu University  Chengdu Sichuan China"},{"name":"Key Laboratory for Animal Science of National Ethnic Affairs Commission Southwest Minzu University  Chengdu Sichuan China"},{"name":"College of Animal Husbandry &amp; Veterinary Medicine Southwest Minzu University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhua","family":"Shen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Qinghai\u2010Tibetan Plateau Animal Genetic Resource Reservation and Utilization of Sichuan Province and Ministry of Education Southwest Minzu University  Chengdu Sichuan China"},{"name":"Key Laboratory for Animal Science of National Ethnic Affairs Commission Southwest Minzu University  Chengdu Sichuan China"},{"name":"College of Animal Husbandry &amp; Veterinary Medicine Southwest Minzu University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujun","family":"Guo","sequence":"additional","affiliation":[{"name":"Key Laboratory of Qinghai\u2010Tibetan Plateau Animal Genetic Resource Reservation and Utilization of Sichuan Province and Ministry of Education Southwest Minzu University  Chengdu Sichuan China"},{"name":"Key Laboratory for Animal Science of National Ethnic Affairs Commission Southwest Minzu University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5470-122X","authenticated-orcid":false,"given":"Xianrong","family":"Xiong","sequence":"additional","affiliation":[{"name":"Key Laboratory of Qinghai\u2010Tibetan Plateau Animal Genetic Resource Reservation and Utilization of Sichuan Province and Ministry of Education Southwest Minzu University  Chengdu Sichuan China"},{"name":"Key Laboratory for Animal Science of National Ethnic Affairs Commission Southwest Minzu University  Chengdu Sichuan China"},{"name":"College of Animal Husbandry &amp; Veterinary Medicine Southwest Minzu University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Qinghai\u2010Tibetan Plateau Animal Genetic Resource Reservation and Utilization of Sichuan Province and Ministry of Education Southwest Minzu University  Chengdu Sichuan China"},{"name":"Key Laboratory for Animal Science of National Ethnic Affairs Commission Southwest Minzu University  Chengdu Sichuan China"},{"name":"College of Animal Husbandry &amp; Veterinary Medicine Southwest Minzu University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Cai","sequence":"additional","affiliation":[{"name":"Key Laboratory of Qinghai\u2010Tibetan Plateau Animal Genetic Resource Reservation and Utilization of Sichuan Province and Ministry of Education Southwest Minzu University  Chengdu Sichuan China"},{"name":"Key Laboratory for Animal Science of National Ethnic Affairs Commission Southwest Minzu University  Chengdu Sichuan China"},{"name":"College of Animal Husbandry &amp; 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