{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T08:59:32Z","timestamp":1767603572254,"version":"3.48.0"},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFD1300502\u20102"],"award-info":[{"award-number":["2023YFD1300502\u20102"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32360831"],"award-info":[{"award-number":["32360831"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012547","name":"Natural Science Foundation of Guangxi Zhuang Autonomous Region","doi-asserted-by":"publisher","award":["2023GXNSFAA026367"],"award-info":[{"award-number":["2023GXNSFAA026367"]}],"id":[{"id":"10.13039\/100012547","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Domestic Animals"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The TGF\u2010\u03b2\/Smad signalling pathway plays a critical regulatory role in mammalian follicular development. Vascular Cell Adhesion Molecule 1 (VCAM1), as a member of the immunoglobulin (Ig) superfamily, is commonly expressed in various cells of the mammalian ovary and affects ovarian development. Previous studies have shown that TGF\u2010\u03b21 is a regulator that down\u2010regulates the expression of VCAM1 in human granulosa cells, but its specific mechanism remains unclear. In this study, we revealed that in porcine follicular granulosa cells, TGF\u2010\u03b21 reduces VCAM1 expression by activating TGF\u2010\u03b2 receptor type I and through the Smad pathway. This down\u2010regulation can be completely reversed by knockdown of Smad2, but not Smad3, suggesting that Smad2 may exert a non\u2010redundant, specialised function in the regulation of VCAM1 by the TGF\u2010\u03b2\/Smad signalling pathway. These results enhance the understanding of the regulatory mechanisms of the TGF\u2010\u03b2 signalling pathway in reproduction and provide a theoretical basis for the regulation of reproductive traits.<\/jats:p>","DOI":"10.1111\/rda.70159","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T12:56:11Z","timestamp":1767012971000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>TGF<\/scp>\n                    \u2010\u03b21 Down\u2010Regulates Vascular Cell Adhesion Molecule 1 in Porcine Follicular Granulosa Cells Through Smad2 Signalling Pathways"],"prefix":"10.1111","volume":"60","author":[{"given":"Yanzi","family":"Lin","sequence":"first","affiliation":[{"name":"Guangxi Key Laboratory of Animal Breeding and Disease Control, College of Animal Science and Technology Guangxi University  Nanning People's Republic of 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