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This developmental window encompasses complex processes of lineage differentiation and morphogenesis. Accumulating evidence indicates that intrinsic defects in embryonic development, most notably within the epiblast, are key contributors to PL, especially following in\u00a0vitro embryo production. Mechanistic investigation of this period has historically been limited by reliance on resource\u2010demanding in\u00a0vivo approaches. In this review, we summarize current knowledge on the molecular regulation of early embryo development in ungulates and the factors associated with PL during the post\u2010hatching period. We further synthesize recent advances in molecular technologies, extended embryo culture systems, and three\u2010dimensional endometrial models that are transforming the study of post\u2010hatching embryo development in livestock species. 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