{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:00:40Z","timestamp":1790838040883,"version":"4.1.0"},"reference-count":8,"publisher":"Wiley","issue":"S3","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007801","name":"Fundaci\u00f3n S\u00e9neca","doi-asserted-by":"publisher","award":["23031\/GERM\/25 supported by FSRM\/10.13039\/100007801"],"award-info":[{"award-number":["23031\/GERM\/25 supported by FSRM\/10.13039\/100007801"]}],"id":[{"id":"10.13039\/100007801","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Domestic Animals"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Efficient reproductive management in commercial swine production requires minimising non\u2010productive days and ensuring rapid return to oestrus after weaning. The present study evaluated the effect of pre\u2010weaning administration of cloprostenol, a PGF2\u03b1 analogue, on early reproductive indicators in sows under commercial farm conditions. A total of 734 clinically healthy multiparous sows (parity 2\u20139) from a commercial farm were randomly allocated to two groups before weaning. Control sows (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009367) received no treatment, whereas treated sows (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009367) received an intramuscular injection of cloprostenol sodium 12\u2009h before piglet removal. Reproductive parameters evaluated included the weaning\u2010to\u2010first\u2010service interval (WFSI), proportion of sows in oestrus within 7\u2009days after weaning, pregnancy rate, early endometritis and abortion rate within the first 42\u2009days of gestation. Sows treated with cloprostenol showed a significantly shorter WFSI compared with control sows (treated: 4.94\u2009\u00b1\u20090.18\u2009days vs. control: 6.41\u2009\u00b1\u20090.27\u2009days;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001) and a higher proportion of oestrus within 7\u2009days after weaning (93.19% vs. 84.2%;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.008). Pregnancy rate and early endometritis incidence were not affected by treatment. However, cloprostenol significantly reduced abortion rate during early gestation (0.55% vs. 3.27%;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.006). Under the conditions of this field study, pre\u2010weaning administration of cloprostenol was associated with a shorter WFSI, a higher proportion of sows showing oestrus within 7\u2009days after weaning, and a lower early abortion rate. These findings suggest that cloprostenol may influence early reproductive indicators in multiparous sows under commercial farm conditions, although further studies including endocrine, ovarian and farrowing outcomes are required.\n                  <\/jats:p>","DOI":"10.1111\/rda.70290","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:11:58Z","timestamp":1790827918000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pre\u2010Weaning Administration of a\n                    <scp>PGF2\u03b1<\/scp>\n                    Analogue (Cloprostenol) and Its Influence on Early Reproductive Indicators in Sows Under Commercial Farm Conditions"],"prefix":"10.1111","volume":"61","author":[{"given":"Sara","family":"Crespo","sequence":"first","affiliation":[{"name":"CEFUSA  Murcia Spain"},{"name":"Department of Physiology University of Murcia, International Excellence Campus for Higher Education and Research \u201cCampus Mare Nostrum\u201d and Biomedical Research Institute of Murcia Pascual Parrilla\u2013IMIB  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3474-7626","authenticated-orcid":false,"given":"Joaqu\u00edn","family":"Gadea","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Murcia, International Excellence Campus for Higher Education and Research \u201cCampus Mare Nostrum\u201d and Biomedical Research Institute of Murcia Pascual Parrilla\u2013IMIB  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0749\u20100720(15)30708\u20108"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2011.07.035"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.103.020461"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/01652176.1994.9694428"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439\u20100531.2006.00717.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0378\u20104320(01)00134\u20108"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.22838"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2024.107440"}],"container-title":["Reproduction in Domestic Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/rda.70290","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/rda.70290","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/rda.70290","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:46:37Z","timestamp":1790837197000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/rda.70290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,30]]},"references-count":8,"journal-issue":{"issue":"S3","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/rda.70290"],"URL":"https:\/\/doi.org\/10.1111\/rda.70290","archive":["Portico"],"relation":{},"ISSN":["0936-6768","1439-0531"],"issn-type":[{"value":"0936-6768","type":"print"},{"value":"1439-0531","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,30]]},"assertion":[{"value":"2026-03-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70290"}}