{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T12:18:36Z","timestamp":1788351516915,"version":"build-2803163510"},"reference-count":52,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T00:00:00Z","timestamp":1787356800000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Domestic Animals"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Subclinical endometritis (SCE) is common in repeat\u2010breeder cows. This study investigated 99 spontaneous consecutive oestrous cycles (pretreatment [C\u20101], culture\u2010sensitive antibiotic treatment [C\u20102], and post\u2010treatment [C\u20103]) in 33 SCE\u2010positive repeat breeders Jersey crossbred cows (out of 43 screened). Clinico\u2010gynaecological (uterine tone, genital discharge, preovulatory follicle, and corpus luteum [CL]), oestrus, and endocrine determinants were compared between C\u20101 and C\u20103. Cows were inseminated up to thrice from C\u20103. A considerable proportion of SCE cows manifested suprabasal P4 concentrations at C\u20101 oestrus. Therefore, apart from overall C\u20101 versus C\u20103 comparisons, the normal (NP4,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200915) and suprabasal (SBP4,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200918) groups were also compared within and between cycles. The prevalence of SCE was 76.74%, with 96.97% of these bacteria\u2010positive at C\u20101 oestrus. The overall comparisons indicated significantly increased discharge consistency and uterine tone, decreased bacterial load, oestrus onset to ovulation interval, and oestrus duration, and increased preovulatory follicle size, oestradiol (E2), and luteinizing hormone (LH), in C\u20103. Also, P4 concentrations in the SBP4 group at C\u20101 oestrus (0.81\u2009\u00b1\u20090.07\u2009ng\/mL) declined significantly at C\u20103 oestrus (0.44\u2009\u00b1\u20090.07\u2009ng\/mL). Nonetheless, compared with NP4, SBP4 had significantly lesser uterine tone (C\u20103), E2, and LH (C\u20101 and C\u20103), and greater bacterial load (C\u20101) (within\u2010cycle effects), as well as a decreased oestrus onset\u2010to\u2010ovulation interval and oestrus duration and increased E2 at C\u20103 (between\u2010cycle effects). The overall pregnancy rate was 75.8%, which had no relation with bacterial presence or load at C\u20103. In conclusion, suprabasal P4 largely accompanied SCE, intriguingly exhibited more reproductive derangements, and resolved after antibiotic therapy targeted against SCE.\n                  <\/jats:p>","DOI":"10.1111\/rda.70309","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T08:14:52Z","timestamp":1787386492000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Subclinical Endometritis\u2010Associated Suprabasal Progesterone and Reproductive Dysfunction in Repeat Breeder Crossbred Cows"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4451-7373","authenticated-orcid":false,"given":"Vijender","family":"Negi","sequence":"first","affiliation":[{"name":"Department of Veterinary Gynaecology and Obstetrics, DGCN College of Veterinary and Animal Sciences CSK Himachal Pradesh Agricultural University  Palampur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8766-3605","authenticated-orcid":false,"given":"Pankaj","family":"Sood","sequence":"additional","affiliation":[{"name":"Department of Veterinary Gynaecology and Obstetrics, DGCN College of Veterinary and Animal Sciences CSK Himachal Pradesh Agricultural University  Palampur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9199-6533","authenticated-orcid":false,"given":"Ankit","family":"Ahuja","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Complex, DGCN College of Veterinary and Animal Sciences CSK Himachal Pradesh Agricultural University  Palampur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit","family":"Mankotia","sequence":"additional","affiliation":[{"name":"Department of Veterinary Gynaecology and Obstetrics, DGCN College of Veterinary and Animal Sciences CSK Himachal Pradesh Agricultural University  Palampur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aarushi","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Veterinary Microbiology, DGCN College of Veterinary and Animal Sciences CSK Himachal Pradesh Agricultural University  Palampur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishant","family":"Kumar","sequence":"additional","affiliation":[{"name":"ICAR\u2010National Dairy Research Institute  Karnal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Kumar","sequence":"additional","affiliation":[{"name":"ICAR\u2010National Research Centre on Pig  Guwahati India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2586-407X","authenticated-orcid":false,"given":"Aanchal","family":"Bakshi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Gynaecology and Obstetrics, DGCN College of Veterinary and Animal Sciences CSK Himachal Pradesh Agricultural University  Palampur India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani12040460"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2222-1808(14)60471-0"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1201\/9780429258589"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4320(00)00169-X"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0093-691X(02)00840-3"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2020.10.018"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2022.08.031"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13620-024-00281-0"},{"key":"e_1_2_8_10_1","volume-title":"Bergey's Manual of Determinative Bacteriology","author":"Bergey D. 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Negi College of Veterinary and Animal Sciences CSK Himachal Pradesh Krishi Vishvavidyalaya Palampur India."},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2010.05.033"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.2105\/MBEF.0222"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.3168\/jdsc.2025\u20100921"},{"key":"e_1_2_8_46_1","volume-title":"Bovine Endometrium Cytotaping Catheter","author":"Sood P.","year":"2025"},{"issue":"2","key":"e_1_2_8_47_1","first-page":"143","article-title":"Prevalence and Certain Characteristics of Mid\u2010Cyclic Estrus in Crossbred Cows","volume":"79","author":"Sood P.","year":"2009","journal-title":"Veterinarski Arhiv"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-14-0598"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1262\/jrd.2017-139"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.55730\/1300-0128.4371"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2017.02.005"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2007.04.056"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.17582\/journal.vsrr\/2021.7.1.58.65"}],"container-title":["Reproduction in Domestic Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/rda.70309","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/rda.70309","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/rda.70309","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:43:17Z","timestamp":1788349397000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/rda.70309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":52,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/rda.70309"],"URL":"https:\/\/doi.org\/10.1111\/rda.70309","archive":["Portico"],"relation":{},"ISSN":["0936-6768","1439-0531"],"issn-type":[{"value":"0936-6768","type":"print"},{"value":"1439-0531","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2026-06-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70309"}}