{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T13:51:59Z","timestamp":1791985919713,"version":"4.4.0"},"reference-count":56,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004263","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio Grande do Sul","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Domestic Animals"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Sanitary sheaths (SS), used to reduce reproductive\u2010tract contamination during bovine artificial insemination (AI), have shown inconsistent associations with pregnancy per AI (P\/AI). This systematic review with meta\u2010analysis evaluated whether SS use improves P\/AI compared with AI without SS. The primary analysis comprised six independent cohorts contributing seven P\/AI strata and 11,367 inseminations. Risk ratios (RRs) were pooled using random\u2010effects models with restricted maximum likelihood estimation and Hartung\u2013Knapp adjustment. The use of SS did not significantly improve P\/AI (RR\u2009=\u20091.07; 95% CI: 0.94\u20131.21;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.245), although the point estimate corresponded to approximately 3.5 additional pregnancies per 100 inseminations. Heterogeneity was moderate (\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u200943.7%), and the 95% prediction interval crossed the null (RR 0.83\u20131.36), indicating that the effect may vary across production settings. Sensitivity analyses did not provide robust evidence of benefit: point estimates ranged from RR 1.07 to 1.10, statistical significance depended on dataset composition, and all prediction intervals crossed the null. Exploratory subgroup analyses showed no evidence that the effect differed by AI method, production system, or protective\u2010sheath type. Overall, current evidence does not demonstrate that SS use improves bovine P\/AI and does not support its routine use as an effective fertility\u2010enhancing intervention; any potential benefit, if present, may be restricted to sanitary and management conditions that remain insufficiently characterised. Future adequately powered randomised trials are needed to determine whether reducing contamination through SS use causally improves fertility.\n                  <\/jats:p>","DOI":"10.1111\/rda.70325","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T13:27:15Z","timestamp":1791984435000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Does the Use of a Sanitary Sheath During Artificial Insemination Improve Pregnancy Outcomes in Cattle? A Systematic Review With Meta\u2010Analysis"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2247-4931","authenticated-orcid":false,"given":"C\u00e9sar Augusto","family":"Pinz\u00f3n\u2010Osorio","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine Universidade Federal de Pelotas (UFPEL)  Pelotas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9254-7037","authenticated-orcid":false,"given":"Alondra","family":"Gonz\u00e1lez\u2010Pati\u00f1o","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine and Animal Science Universidad Aut\u00f3noma de Nuevo Le\u00f3n  Monterrey Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8593-0367","authenticated-orcid":false,"given":"Daniela","family":"Cortes\u2010Beltran","sequence":"additional","affiliation":[{"name":"Department of Large Animal Medicine and Surgery, College of Veterinary Medicine University of Georgia  Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.animal.2024.101410"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jas\/skz210"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2024.10.004"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2010\u20103704"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmy012"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2016\u201011623"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imr.2023.101014"},{"key":"e_1_2_12_9_1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/B978-0-08-102170-5.00009-9","volume-title":"A Guide to the Manufacture, Performance, and Potential of Plastics in Agriculture","author":"Borreani G.","year":"2017"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0290337"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.repbio.2015.12.002"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0093\u2010691X(05)80016\u20100"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.32473\/edis\u2010an391\u20102024"},{"issue":"10","key":"e_1_2_12_14_1","article-title":"Updated Guidance for Trusted Systematic Reviews: A New Edition of the Cochrane Handbook for Systematic Reviews of Interventions","volume":"2019","author":"Cumpston M.","year":"2019","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"10","key":"e_1_2_12_15_1","article-title":"Assessment of Listing and Categorisation of Animal Diseases Within the Framework of the Animal Health Law (Regulation (EU) No 2016\/429): Trichomonosis","volume":"15","author":"Depner K.","year":"2017","journal-title":"EFSA Journal"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/jas\/skz258.491"},{"key":"e_1_2_12_17_1","volume-title":"Assessment of Agricultural Plastics and Their Sustainability: A Call for Action","author":"FAO, X","year":"2021"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201061704\u20100"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751\u20100813.2008.00326.x"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102288\u201014\u201043"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2018\u201016082"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439\u20100531.1991.tb01543.x"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mjafi.2022.07.009"},{"issue":"2","key":"e_1_2_12_24_1","first-page":"103","article-title":"The Use of Artificial Insemination Gun Protective Plastic Sheath at the Time of Artificial Insemination Did Not Improve Fertility of Beef Cattle","volume":"8","author":"Kasimanickam R.","year":"2016","journal-title":"Clinical Theriogenology"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2008.08.005"},{"issue":"8","key":"e_1_2_12_26_1","first-page":"327","article-title":"Routine Use of Protective Sheaths in Cattle Inseminations Did Not Improve Fertility","volume":"25","author":"King G.","year":"1984","journal-title":"Canadian Veterinary Journal"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2011.10.014"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1262\/jrd.2022\u2010124"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/jas\/skaa178"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0200974"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2023.07.037"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2024.1385505"},{"key":"e_1_2_12_33_1","unstructured":"Morales Gonz\u00e1lez L. R. A.Menchaca andR.N\u00fa\u00f1ez Olivera.2023. \u201cUso de camisa sanitaria en la c\u00e1nula de inseminaci\u00f3n para mejorar la tasa de pre\u00f1ez en bovinos.\u201dhttps:\/\/www.colibri.udelar.edu.uy\/jspui\/handle\/20.500.12008\/42436."},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2021.11.007"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11250\u2010021\u201002937\u20103"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2016\u201011348"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2016\u201011529"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2025.108077"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1071\/RD25165"},{"key":"e_1_2_12_40_1","article-title":"Taxa de prenhez na primeira e segunda IATF de vacas Nelore inseminadas com ou sem uso de camisinha sanit\u00e1ria","volume":"10","author":"Rezende R.","year":"2022","journal-title":"Anais Da XXXV Reuni\u00e3o Anual Da Sociedade Brasileira de Tecnologia de Embri\u00f5es"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0093\u2010691X(84)90388\u20101"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/171749a0"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2010.05.033"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2010\u20103668"},{"issue":"4","key":"e_1_2_12_45_1","first-page":"28","article-title":"The Effect of AI Sheaths on the Pregnancy Rate of Dairy Cattle","volume":"19","author":"Scariot C. A.","year":"2022","journal-title":"Animal Reproduction"},{"issue":"3","key":"e_1_2_12_46_1","first-page":"1","article-title":"The Use of Protective AI Cover Sheaths Improved Fertility in Lactating Dairy Cows","volume":"3","author":"Schuenemann G.","year":"2011","journal-title":"Clinical Theriogenology"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439\u20100531.2009.01465.x"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2005.08.021"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009192"},{"key":"e_1_2_12_50_1","unstructured":"Silva P. H. M. J. P. R.Bueno andF. H.Litz.2020.Uso de camisa sanit\u00e1ria sobre a taxa de prenhez bovina durante a insemina\u00e7\u00e3o artificial. Anais do Congresso Brasileiro Interdisciplinar em Ci\u00eancia e Tecnologia.https:\/\/www.even3.com.br\/anais\/icobicet2020\/262645\u2010uso\u2010de\u2010camisa\u2010sanitaria\u2010sobre\u2010a\u2010taxa\u2010de\u2010prenhez\u2010bovina\u2010durante\u2010a\u2010inseminacao\u2010artificial."},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.3389\/fanim.2024.1399337"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.55730\/1300\u20100128.4339"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917\u2010014\u20100280\u2010x"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/rda.13918"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.12968\/live.2020.25.1.13"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022\u20100302(07)71600\u20104"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1590\/1984\u20103143\u2010AR2024\u20100063"}],"container-title":["Reproduction in Domestic Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/rda.70325","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/rda.70325","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/rda.70325","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T13:27:21Z","timestamp":1791984441000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/rda.70325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":56,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/rda.70325"],"URL":"https:\/\/doi.org\/10.1111\/rda.70325","archive":["Portico"],"relation":{},"ISSN":["0936-6768","1439-0531"],"issn-type":[{"value":"0936-6768","type":"print"},{"value":"1439-0531","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2026-08-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70325"}}