{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:31:02Z","timestamp":1791178262321,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,1,25]],"date-time":"2013-01-25T00:00:00Z","timestamp":1359072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Many lung diseases arise as the consequence of inhalational injury. When pathogenic materials are inhaled, it is possible that their clearance routes become the main focus of injury in the lung. Lymphatic clearance is important in the removal from the lung of small inhaled particles. The leak of toxic agents from the lymphatic flow potentially explains the topographic distribution of diffuse lung diseases triggered by inhaled materials, for example asbestosis. The aim of this study was to evaluate the differences in lymphatic distribution across various craniocaudal levels of the lung by using carbon dust deposition (<jats:styled-content style=\"fixed-case\">CDD<\/jats:styled-content>) as a tracing marker.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated 61 HE\u2010stained slides of the normal lung area from 61 lobectomy specimens. The intensity of <jats:styled-content style=\"fixed-case\">CDD<\/jats:styled-content> was scored into five degrees (0\u20134) in bronchiolovascular (<jats:styled-content style=\"fixed-case\">BV<\/jats:styled-content>) areas and subpleural\/septal (<jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>) areas per slide. The distribution was highlighted by subtraction scores of <jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content> areas from those of bronchiolovascular areas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The subtraction scores of the upper lung area were significantly greater than those in the lower area, whereas there was no significant difference in scores by pulmonary lobes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results indicated that the main lymphatic clearance routes vary according to the craniocaudal levels, and are predominant in <jats:styled-content style=\"fixed-case\">BV<\/jats:styled-content> areas of the upper areas and in <jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content> areas of the lower areas of the lung. This may explain the histological variations in anatomical distribution observed in the biopsy specimens of some diffuse lung diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12006","type":"journal-article","created":{"date-parts":[[2012,11,2]],"date-time":"2012-11-02T12:27:01Z","timestamp":1351859221000},"page":"348-353","source":"Crossref","is-referenced-by-count":17,"title":["Differential distribution of lymphatic clearance between upper and lower regions of the lung"],"prefix":"10.1111","volume":"18","author":[{"given":"RYOKO","family":"EGASHIRA","sequence":"first","affiliation":[{"name":"Department of Surgical Pathology Toyama University Hospital"},{"name":"Department of Radiology Faculty of Medicine Saga University  Saga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TOMONORI","family":"TANAKA","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology Toyama University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TAKESHI","family":"IMAIZUMI","sequence":"additional","affiliation":[{"name":"Department of Radiology Faculty of Medicine Saga University  Saga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KAZUTAKA","family":"SENDA","sequence":"additional","affiliation":[{"name":"1st Department of Surgery Toyama Thoracic Society University of Toyama  Toyama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YOSHINORI","family":"DOKI","sequence":"additional","affiliation":[{"name":"1st Department of Surgery Toyama Thoracic Society University of Toyama  Toyama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SHO","family":"KUDO","sequence":"additional","affiliation":[{"name":"Department of Radiology Faculty of Medicine Saga University  Saga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JUNYA","family":"FUKUOKA","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology Toyama University Hospital"},{"name":"Department of Toyama Thoracic Society Toyama University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,1,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.165.2.ats01"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(71)91501-7"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.74.4.426"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.167.2.3282257"},{"key":"e_1_2_7_6_1","first-page":"358","article-title":"\u2018State of the art\u2019 review. 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