{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:17:18Z","timestamp":1765887438636},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,3,21]],"date-time":"2013-03-21T00:00:00Z","timestamp":1363824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>We evaluated the association between activities of daily living and drug\u2010induced liver injury by anti\u2010tuberculosis drugs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort study included adult inpatients with newly diagnosed smear\u2010positive lung tuberculosis treated with standard regimen in two hospitals. (<jats:italic>n<\/jats:italic>\u2009=\u2009346; 63.6\u2009\u00b1\u200920.3 years old; 106 (30.6%) females). Activities of daily living was divided into \u2018independent\u2019 (<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>arthel <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>ndex (<jats:styled-content style=\"fixed-case\">BI<\/jats:styled-content>) 80\u2013100, 60.4%) and \u2018decreased\u2019 (<jats:styled-content style=\"fixed-case\">BI<\/jats:styled-content> 0\u201375, 39.6%) categories. Liver injury was defined as the withdrawal or change of treatment regimen on the basis of the following criteria: serum transaminase concentrations were more than three times the upper limit of normal range with jaundice and\/or hepatitis symptoms, or more than five times the upper limit of the normal range.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with \u2018independent\u2019 patients, patients with \u2018decreased\u2019 activities of daily living had odds ratios for liver injury of 4.2 (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009&lt;\u20090.001) in univariate analysis and 5.7 (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.002) in logistic regression analysis after adjusting for other risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Decreased activity of daily living is a strong risk factor for liver injury among adult inpatients with newly diagnosed smear\u2010positive lung tuberculosis treated using a standard regimen.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12008","type":"journal-article","created":{"date-parts":[[2012,11,5]],"date-time":"2012-11-05T13:46:09Z","timestamp":1352123169000},"page":"474-479","source":"Crossref","is-referenced-by-count":13,"title":["Decreased activities of daily living is a strong risk factor for liver injury by anti\u2010tuberculosis drugs"],"prefix":"10.1111","volume":"18","author":[{"given":"Nobuyuki","family":"Horita","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Clinical Immunology Yokohama City University Graduate School of Medicine  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Miyazawa","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Saiseikai Yokohamashi Nanbu Hospital  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Yoshiyama","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Fukujuji Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshinori","family":"Tsukahara","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Immunology Yokohama City University Graduate School of Medicine  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryohei","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Immunology Yokohama City University Graduate School of Medicine  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Tsukiji","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Immunology Yokohama City University Graduate School of Medicine  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Immunology Yokohama City University Graduate School of Medicine  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Respiratory Disease Center Yokohama City University Medical Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiaki","family":"Ishigatsubo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Immunology Yokohama City University Graduate School of Medicine  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200510-1666ST"},{"key":"e_1_2_7_3_1","first-page":"1854","article-title":"ATS, CDC, and IDSA update recommendations on the treatment of tuberculosis","volume":"68","author":"Neff M","year":"2003","journal-title":"Am. 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