{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T20:43:53Z","timestamp":1785012233695,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,3,21]],"date-time":"2013-03-21T00:00:00Z","timestamp":1363824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Whether the therapeutic nasal continuous positive airway pressure (<jats:styled-content style=\"fixed-case\">CPAP<\/jats:styled-content>) derived from manual titration is the same as derived from automatic titration is controversial. The purpose of this study was to compare the therapeutic pressure derived from manual titration with automatic titration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010one patients with obstructive sleep apnoea (<jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content>) (mean apnoea\/hypopnoea index (<jats:styled-content style=\"fixed-case\">AHI<\/jats:styled-content>)\u2009=\u200950.6\u2009\u00b1\u200918.6 events\/h) who were newly diagnosed after an overnight full polysomnography and who were willing to accept <jats:styled-content style=\"fixed-case\">CPAP<\/jats:styled-content> as a long\u2010term treatment were recruited for the study. Manual titration during full polysomnography monitoring and unattended automatic titration with an automatic <jats:styled-content style=\"fixed-case\">CPAP<\/jats:styled-content> device (<jats:styled-content style=\"fixed-case\">REM<\/jats:styled-content>star Auto) were performed. A separate cohort study of one hundred patients with <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">AHI<\/jats:styled-content>\u2009=\u200954.3\u2009\u00b1\u200918.9 events\/h) was also performed by observing the efficacy of <jats:styled-content style=\"fixed-case\">CPAP<\/jats:styled-content> derived from manual titration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The treatment pressure derived from automatic titration (9.8\u2009\u00b1\u20092.2\u2009cm<jats:styled-content style=\"fixed-case\">H<jats:sub>2<\/jats:sub>O<\/jats:styled-content>) was significantly higher than that derived from manual titration (7.3\u2009\u00b1\u20091.5\u2009cm<jats:styled-content style=\"fixed-case\">H<jats:sub>2<\/jats:sub>O<\/jats:styled-content>; <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009&lt;\u20090.001) in 51 patients. The cohort study of 100 patients showed that <jats:styled-content style=\"fixed-case\">AHI<\/jats:styled-content> was satisfactorily decreased after <jats:styled-content style=\"fixed-case\">CPAP<\/jats:styled-content> treatment using a pressure derived from manual titration (54.3\u2009\u00b1\u200918.9 events\/h before treatment and 3.3\u2009\u00b1\u20091.7 events\/h after treatment; <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results suggest that automatic titration pressure derived from <jats:styled-content style=\"fixed-case\">REM<\/jats:styled-content>star Auto is usually higher than the pressure derived from manual titration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12014","type":"journal-article","created":{"date-parts":[[2012,11,12]],"date-time":"2012-11-12T17:03:51Z","timestamp":1352739831000},"page":"528-533","source":"Crossref","is-referenced-by-count":23,"title":["Comparison of manual versus automatic continuous positive airway pressure titration and the development of a predictive equation for therapeutic continuous positive airway pressure in <scp>C<\/scp>hinese patients with obstructive sleep apnoea"],"prefix":"10.1111","volume":"18","author":[{"given":"Jiaying","family":"Luo","sequence":"first","affiliation":[{"name":"Sleep Center State Key Laboratory of Respiratory Disease Guangzhou Medical College  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sichang","family":"Xiao","sequence":"additional","affiliation":[{"name":"Sleep Center State Key Laboratory of Respiratory Disease Guangzhou Medical College  Guangzhou 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