{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T19:10:59Z","timestamp":1790968259920,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,3,21]],"date-time":"2013-03-21T00:00:00Z","timestamp":1363824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2013,4]]},"abstract":"Abstract<\/jats:title>Background and objective<\/jats:title>Nutritional depletion in chronic obstructive pulmonary disease (COPD<\/jats:styled-content>) adversely affects health status and mortality. We aimed to evaluate the effects of nutritional supplementation (NS<\/jats:styled-content>) with pulmonary rehabilitation (PR<\/jats:styled-content>) on body composition, mid\u2010thigh cross\u2010sectional area (CSA<\/jats:styled-content>), dyspnoea, exercise capacity, health\u2010related quality of life, anxiety and depression in advanced COPD<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>Methods<\/jats:title>Forty\u2010six patients were randomized to PR<\/jats:styled-content> and nutritional support (PRNS<\/jats:styled-content>), PR<\/jats:styled-content> or the control group. Dyspnoea was measured with M<\/jats:styled-content>edical R<\/jats:styled-content>esearch C<\/jats:styled-content>ouncil and BORG<\/jats:styled-content> scales. Exercise capacity was measured through 6\u2010min walk test and shuttle tests; health\u2010related quality of life was assessed with S<\/jats:styled-content>t. G<\/jats:styled-content>eorge's R<\/jats:styled-content>espiratory Q<\/jats:styled-content>uestionnaire. Psychological status was measured with H<\/jats:styled-content>ospital A<\/jats:styled-content>nxiety and D<\/jats:styled-content>epression S<\/jats:styled-content>cale. Body weight and body mass indexes (BMI<\/jats:styled-content>) were also evaluated. Fat\u2010free mass was measured through bioelectrical impedance analyser. The CSA<\/jats:styled-content> of quadriceps was calculated in mid\u2010level of the thigh with magnetic resonance imaging.<\/jats:p><\/jats:sec>Results<\/jats:title>Dyspnoea and total scores of S<\/jats:styled-content>t. G<\/jats:styled-content>eorge's R<\/jats:styled-content>espiratory Q<\/jats:styled-content>uestionnaire improved in both groups (P<\/jats:styled-content><\/jats:italic>\u2009<\u20090.05). Six\u2010minute walk test and incremental shuttle walk test distances in PRNS<\/jats:styled-content> and PR<\/jats:styled-content> patients increased significantly as (62.6\u2009\u00b1\u200942.4\u2009m, 43.3\u2009\u00b1\u200959.2\u2009m, both P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.001; and 63.3\u2009\u00b1\u200970.1\u2009m and 69.3\u2009\u00b1\u200969.7\u2009m, both P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.001). Although anxiety improved in both groups (P<\/jats:styled-content><\/jats:italic>\u2009<\u20090.05), there was no change in depression. Body weight, BMI<\/jats:styled-content> and fat\u2010free mass index (FFMI<\/jats:styled-content>) (1.1\u2009\u00b1\u20090.9\u2009kg, 0.2\u2009\u00b1\u20091.4\u2009kg\/m2<\/jats:sup> and 0.6\u2009\u00b1\u20090.5\u2009kg\/m2<\/jats:sup>, P<\/jats:styled-content><\/jats:italic>\u2009<\u20090.05) in PRNS<\/jats:styled-content>, whereas body weight and FFMI<\/jats:styled-content> (0.6\u2009\u00b1\u20090.7\u2009kg, 0.1\u2009\u00b1\u20090.6\u2009kg\/m2<\/jats:sup> P<\/jats:styled-content><\/jats:italic>\u2009<\u20090.05) increased in PR<\/jats:styled-content> after the intervention. There was a significant increase in mid\u2010thigh CSA<\/jats:styled-content> (2.5\u2009\u00b1\u20094.1\u2009cm2<\/jats:sup>) only in PRNS<\/jats:styled-content> (P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.04).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The combination of NS<\/jats:styled-content> with PR<\/jats:styled-content> resulted in improvements particularly in lean body mass and mid\u2010thigh CSA<\/jats:styled-content>. This study suggests combining NS<\/jats:styled-content> with PR<\/jats:styled-content> in reversing weight loss and muscle wasting in COPD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12019","type":"journal-article","created":{"date-parts":[[2012,11,20]],"date-time":"2012-11-20T15:51:40Z","timestamp":1353426700000},"page":"495-500","source":"Crossref","is-referenced-by-count":57,"title":["Effects of nutritional supplementation combined with conventional pulmonary rehabilitation in muscle\u2010wasted chronic obstructive pulmonary disease: A prospective, randomized and controlled study"],"prefix":"10.1111","volume":"18","author":[{"given":"Alev","family":"Gurgun","sequence":"first","affiliation":[{"name":"Department of Chest Diseases Ege University School of Medicine Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sami","family":"Deniz","sequence":"additional","affiliation":[{"name":"Department of Chest Diseases Ege University School of Medicine Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Arg\u0131n","sequence":"additional","affiliation":[{"name":"Department of Radiology Ege University School of Medicine Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hale","family":"Karapolat","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy and Rehabilitation Ege University School of Medicine Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e3283023d37"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2004.09.024"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0738-3991(03)00099-5"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/82.1.53"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00063198-200003000-00005"},{"key":"e_1_2_7_7_1","unstructured":"National Institute for Health and Clinical Excellence.Chronic obstructive pulmonary disease: management of adults with chronic obstructive pulmonary disease in primary and secondary care. 2010. Update guideline to be published in June 2010. [accessed 24 Apr 2010.] Available from URL:tinyurl.com\/nice\u2010copd"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1806-37132006000500014"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/137.5.1075"},{"key":"e_1_2_7_10_1","unstructured":"Global Initiative for Chronic Obstructive Lung Disease (GOLD).Global strategy for the diagnosis management and prevention of COPD. [Accessed 15 Sep 2011.] Available from URL:http:\/\/www.goldcopd.org\/"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(02)00841-9"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200508-1211ST"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.166.1.at1102"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.47.12.1019"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.54.3.213"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61047-7"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2009.01.023"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2005.04.007"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.167.1.60"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2004.03.003"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.12968\/bjon.2010.19.9.48054"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2005.01.005"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2107031"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000998.pub2"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20070052"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2010.05.008"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.111.023499"}],"container-title":["Respirology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fresp.12019","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/resp.12019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T19:01:27Z","timestamp":1697310087000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/resp.12019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,21]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["10.1111\/resp.12019"],"URL":"https:\/\/doi.org\/10.1111\/resp.12019","archive":["Portico"],"relation":{},"ISSN":["1323-7799","1440-1843"],"issn-type":[{"value":"1323-7799","type":"print"},{"value":"1440-1843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,21]]}}}