{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T16:19:54Z","timestamp":1777997994336,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,3,21]],"date-time":"2013-03-21T00:00:00Z","timestamp":1363824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Aspiration pneumonia is one of the common presentations of community\u2010acquired pneumonia (<jats:styled-content style=\"fixed-case\">CAP<\/jats:styled-content>) and healthcare\u2010associated pneumonia (<jats:styled-content style=\"fixed-case\">HCAP<\/jats:styled-content>). However, its significance has not yet been fully evaluated due to the difficulties associated with the diagnosis of this condition. This study aimed to evaluate the impact of objectively defined aspiration pneumonia on patients' prognosis with <jats:styled-content style=\"fixed-case\">CAP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HCAP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a multicenter retrospective cohort study consisting of 417 <jats:styled-content style=\"fixed-case\">CAP<\/jats:styled-content> and 220 <jats:styled-content style=\"fixed-case\">HCAP<\/jats:styled-content> patients. We defined aspiration pneumonia as having both risk factors for aspiration (dysphagia due to a neurological disorder, or disturbance of consciousness) and evidence of gravity\u2010dependent opacity on chest computed tomography (<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>). The prognostic factors for 30\u2010day mortality were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred sixteen (18%) patients met the definition of aspiration pneumonia, 72 (11%) patients had risks for aspiration alone, 129 (20%) patients had <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> findings consistent with aspiration alone, and 320 (50%) patients had neither. Patients diagnosed with aspiration pneumonia had a significantly worse survival than those with risk factors alone (<jats:italic>P<\/jats:italic>\u2009=\u20090.001), <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> findings of aspiration alone (<jats:italic>P<\/jats:italic>\u2009=\u20090.009) and neither (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). A multivariate analysis indicated that aspiration pneumonia was independently associated with increased 30\u2010day mortality (adjusted hazard ratio 5.690, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) after adjusting for other variables, including the category of pneumonia, performance status, the severity score (<jats:styled-content style=\"fixed-case\">CURB<\/jats:styled-content>\u201065) and treatment failure due to resistant pathogens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Aspiration pneumonia may be a significant predictor of mortality among <jats:styled-content style=\"fixed-case\">CAP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HCAP<\/jats:styled-content> patients. Therefore, the concept of aspiration pneumonia should be considered in the guidelines for these types of pneumonia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12029","type":"journal-article","created":{"date-parts":[[2012,12,12]],"date-time":"2012-12-12T06:47:29Z","timestamp":1355294849000},"page":"514-521","source":"Crossref","is-referenced-by-count":97,"title":["Impact of aspiration pneumonia in patients with community\u2010acquired pneumonia and healthcare\u2010associated pneumonia: A multicenter retrospective cohort study"],"prefix":"10.1111","volume":"18","author":[{"given":"Kosaku","family":"Komiya","sequence":"first","affiliation":[{"name":"Internal Medicine 2 Oita University  Oita"},{"name":"Clinical Research Center of Respiratory Medicine Tenshindo Hetsugi Hospital  Oita"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Ishii","sequence":"additional","affiliation":[{"name":"Internal Medicine 2 Oita University  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