{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T23:28:57Z","timestamp":1715210937354},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,3,21]],"date-time":"2013-03-21T00:00:00Z","timestamp":1363824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2013,4]]},"abstract":"Abstract<\/jats:title>Background and objective<\/jats:title>The role of pro\u2010inflammatory interleukin\u201017A<\/jats:styled-content> (IL<\/jats:styled-content>\u201017A<\/jats:styled-content>), in pleural diseases is unknown. We sought to investigate IL<\/jats:styled-content>\u201017A<\/jats:styled-content> expression and its clinical implications in patients with pleural effusion (PE<\/jats:styled-content>) and IL<\/jats:styled-content>\u201017A<\/jats:styled-content> involvement in the pathobiology of pleural inflammation elicited by bacterial products.<\/jats:p><\/jats:sec>Methods<\/jats:title>Pleural and blood IL<\/jats:styled-content>\u201017A<\/jats:styled-content> content was examined in 84 patients with PE<\/jats:styled-content> of different aetiologies, and the diagnostic value of pleural IL<\/jats:styled-content>\u201017A<\/jats:styled-content> was explored in 92 patients with neutrophil\u2010predominant PE<\/jats:styled-content>. IL<\/jats:styled-content>\u201017A<\/jats:styled-content> contribution in pleural inflammation was evaluated in mice injected intrapleurally with either IL<\/jats:styled-content>\u201017A<\/jats:styled-content> or bacterial products with or without IL<\/jats:styled-content>\u201017A<\/jats:styled-content>\u2010neutralizing antibodies.<\/jats:p><\/jats:sec>Results<\/jats:title>IL<\/jats:styled-content>\u201017A<\/jats:styled-content> was upregulated in the pleural space of patients with parapneumonic PE<\/jats:styled-content>. It was detected in a minority of patients with tuberculous PE<\/jats:styled-content> and very uncommonly in patients with malignant or other pleural exudates. Pleural fluid (PF<\/jats:styled-content>) IL<\/jats:styled-content>\u201017A<\/jats:styled-content> levels were correlated with markers of acute pleural inflammation, as well as vascular endothelial growth factor and IL<\/jats:styled-content>\u20108 levels. Among patients with neutrophil\u2010predominant PE<\/jats:styled-content>, PF IL<\/jats:styled-content>\u201017A<\/jats:styled-content> was detected only in those with parapneumonic PE<\/jats:styled-content>, although the sensitivity of the test was low (<50%). Intrapleural injection of IL<\/jats:styled-content>\u201017A<\/jats:styled-content> elicited a neutrophil\u2010predominant inflammatory response in mice, and IL<\/jats:styled-content>\u201017A<\/jats:styled-content> neutralization partially blocked pleural neutrophilia induced by intrapleural administration of bacterial products.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>IL<\/jats:styled-content>\u201017A<\/jats:styled-content> is involved in pleural inflammation related to bacterial infection. Moreover, pleural IL<\/jats:styled-content>\u201017A<\/jats:styled-content> levels may be helpful in uncovering an infectious aetiology among patients with neutrophil\u2010predominant PE<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12030","type":"journal-article","created":{"date-parts":[[2012,12,13]],"date-time":"2012-12-13T17:20:04Z","timestamp":1355419204000},"page":"488-494","source":"Crossref","is-referenced-by-count":8,"title":["Interleukin\u201017A<\/scp> is involved in bacteria\u2010related acute pleural inflammation"],"prefix":"10.1111","volume":"18","author":[{"given":"Androniki","family":"Kollintza","sequence":"first","affiliation":[{"name":"Applied Biomedical Research and Training Center \u2018Marianthi Simou\u2019 Department of Critical Care and Pulmonary Services, General Hospital \u2018Evangelismos\u2019 School of Medicine National and Kapodistrian University of Athens 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Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charalampos","family":"Moschos","sequence":"additional","affiliation":[{"name":"Applied Biomedical Research and Training Center \u2018Marianthi Simou\u2019 Department of Critical Care and Pulmonary Services, General Hospital \u2018Evangelismos\u2019 School of Medicine National and Kapodistrian University of Athens Athens"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalini","family":"Stratiki","sequence":"additional","affiliation":[{"name":"Applied Biomedical Research and Training Center \u2018Marianthi Simou\u2019 Department of Critical Care and Pulmonary Services, General Hospital \u2018Evangelismos\u2019 School of Medicine National and Kapodistrian University of Athens Athens"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aureli","family":"Esquerda","sequence":"additional","affiliation":[{"name":"Pleural Diseases Unit Department of Internal Medicine Arnau de Vilanova 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