{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:23:13Z","timestamp":1791116593231,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,4,25]],"date-time":"2013-04-25T00:00:00Z","timestamp":1366848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2013,5]]},"abstract":"Abstract<\/jats:title>Background and objective<\/jats:title>We have suggested that chronic inflammation of other foregut derivatives might be associated with airway inflammation and amplification of the response to inhaled stimuli such as cigarette smoke leading to chronic obstructive pulmonary disease (COPD<\/jats:styled-content>). One of the commonest causes of chronic foregut inflammation is gastritis secondary to H<\/jats:styled-content>elicobacter Pylori<\/jats:italic> infection. We tested the hypothesis that peptic ulceration and H<\/jats:styled-content>.\u2009Pylori<\/jats:italic> seropositivity are associated with COPD<\/jats:styled-content> independently of other shared risk factors.<\/jats:p><\/jats:sec>Methods<\/jats:title>We reviewed primary care medical records and performed full lung function tests on 329 miners seen over 2 years as part of a compensation scheme. We also performed H<\/jats:styled-content>.\u2009Pylori<\/jats:italic> serology in patients with varying degrees of severity of COPD<\/jats:styled-content> compared with a matched control population.<\/jats:p><\/jats:sec>Results<\/jats:title>The prevalence of peptic ulcer disease in the groups classed as normal, chronic bronchitis, mild, moderate and severe COPD<\/jats:styled-content> was 3.2%, 16.2%, 21.4%, 42.4% and 56.2%, respectively. There was a strong and independent relationship between the presence of peptic ulcer disease and percent of predicted forced expiratory volume in 1\u2009s (\u221213.3%; 95% confidence interval: 6.7\u201319.9; P<\/jats:styled-content><\/jats:italic>\u2009<\u20090.001) and forced expiratory volume in 1\u2009s\/forced vital capacity ratio (\u22125.06%; 95% confidence interval: 1.8\u20138.2; P<\/jats:styled-content><\/jats:italic>\u2009<\u20090.001). Positive H<\/jats:styled-content>.\u2009pylori<\/jats:italic> serology was present in 54.7% of 58 patients with COPD<\/jats:styled-content> and 23.5% of 17 controls (P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.026).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Our findings suggest a relationship between peptic ulcer disease and COPD<\/jats:styled-content> that is more that just a shared susceptibility to different environmental stimuli.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12075","type":"journal-article","created":{"date-parts":[[2013,2,26]],"date-time":"2013-02-26T08:11:12Z","timestamp":1361866272000},"page":"728-731","source":"Crossref","is-referenced-by-count":31,"title":["Peptic ulceration, Helicobacter pylori<\/i> seropositivity and chronic obstructive pulmonary disease"],"prefix":"10.1111","volume":"18","author":[{"given":"Roshan","family":"Siva","sequence":"first","affiliation":[{"name":"Institute for Lung Health Department of Respiratory Medicine and Thoracic Surgery Glenfield Hospital Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surinder S.","family":"Birring","sequence":"additional","affiliation":[{"name":"Institute for Lung Health Department of Respiratory Medicine and Thoracic Surgery Glenfield Hospital Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Berry","sequence":"additional","affiliation":[{"name":"Institute for Lung Health Department of Respiratory Medicine and Thoracic Surgery Glenfield Hospital Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Rowbottom","sequence":"additional","affiliation":[{"name":"Institute for Lung Health Department of Respiratory Medicine and Thoracic Surgery Glenfield Hospital Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian D.","family":"Pavord","sequence":"additional","affiliation":[{"name":"Institute for Lung Health Department of Respiratory Medicine and Thoracic Surgery Glenfield Hospital Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,4,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.5.2101039"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00040703"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.121.3_suppl.1S-a"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.01.17509820"},{"key":"e_1_2_7_6_1","unstructured":"PatelRB BirringSS KirkSet\u2009al.Airway function and markers of airway inflammation in patients with treated hypothyroidism.Abstract BTS 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