{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:38:07Z","timestamp":1792093087517,"version":"4.4.0"},"reference-count":9,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,6,21]],"date-time":"2013-06-21T00:00:00Z","timestamp":1371772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2013,7]]},"abstract":"Abstract<\/jats:title>Background and objective<\/jats:title>Patients with chronic obstructive pulmonary disease (COPD<\/jats:styled-content>) presenting with acute hypercapnic respiratory failure (AHcRF<\/jats:styled-content>) benefit from non\u2010invasive ventilation (NIV<\/jats:styled-content>). The best way to withdraw NIV<\/jats:styled-content> is not known, and we conducted a pilot study comparing stepwise versus immediate withdrawal of NIV<\/jats:styled-content> in these patients.<\/jats:p><\/jats:sec>Methods<\/jats:title>This was a prospective, single\u2010centre, open\u2010labelled randomized study comparing stepwise versus immediate withdrawal of NIV<\/jats:styled-content> in patients with COPD<\/jats:styled-content> exacerbation recovering from AHcRF<\/jats:styled-content>. The primary end\u2010point was the success rate of NIV<\/jats:styled-content> withdrawal, defined as no restarting of NIV<\/jats:styled-content> from randomization to 48\u2009h after complete withdrawal of NIV<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>Sixty patients were randomized, 35 patients to stepwise withdrawal and 25 patients to immediate withdrawal. The two study arms were clinically comparable. There was no statistically significant difference in the success rate, with NIV<\/jats:styled-content> successfully stopped in 74.3% and 56% in the stepwise and immediate withdrawal groups, respectively (P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.139).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>We could not show any benefits for either strategy to withdraw NIV<\/jats:styled-content>. The study may have been underpowered to detect differences, and larger prospective studies are required.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12080","type":"journal-article","created":{"date-parts":[[2013,3,14]],"date-time":"2013-03-14T00:33:59Z","timestamp":1363221239000},"page":"814-819","source":"Crossref","is-referenced-by-count":30,"title":["A pilot randomized study comparing two methods of non\u2010invasive ventilation withdrawal after acute respiratory failure in chronic obstructive pulmonary disease"],"prefix":"10.1111","volume":"18","author":[{"given":"Chung\u2010Tat","family":"Lun","sequence":"first","affiliation":[{"name":"Division of Respiratory Medicine Department of Medicine United Christian Hospital Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica L.","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine Department of Medicine United Christian Hospital Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wah\u2010Shing","family":"Leung","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine Department of Medicine United Christian Hospital Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice P.S.","family":"Cheung","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine Department of Medicine United Christian Hospital Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suet\u2010Lai","family":"Cheng","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine Department of Medicine United Christian Hospital Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda S.N.","family":"Tsui","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine Department of Medicine United Christian Hospital Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung\u2010Ming","family":"Chu","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine Department of Medicine United Christian Hospital Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,6,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200203000-00010"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.326.7382.185"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004104.pub3"},{"key":"e_1_2_7_5_1","unstructured":"BTS\/RCP London\/Intensive Care Society.The use of non\u2010invasive ventilation in the management of patients with chronic obstructive pulmonary disease admitted to hospital with acute type II respiratory failure (with particular reference to Bilevel positive pressure ventilation). Date last updated: October 2008. [Assessed 22 Mar 2013.] Available from URL:http:\/\/www.brit\u2010thoracic.org.uk\/guidelines\/nippv\u2010%E2%80%93\u2010niv\u2010in\u2010acute\u2010respiratory\u2010failure\u2010guideline.aspx"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02323-0"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199502093320601"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.150.4.7921460"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.120.6_suppl.375S"},{"key":"e_1_2_7_10_1","first-page":"A6489","article-title":"Withdrawal of non\u2010invasive ventilation in acute hypercarpnic respiratory failure: randomised controlled trial","volume":"185","author":"Sellares J","year":"2012","journal-title":"Am. J. Respir. Crit. Care Med."}],"container-title":["Respirology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fresp.12080","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/resp.12080","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T12:54:57Z","timestamp":1695992097000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/resp.12080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,21]]},"references-count":9,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1111\/resp.12080"],"URL":"https:\/\/doi.org\/10.1111\/resp.12080","archive":["Portico"],"relation":{},"ISSN":["1323-7799","1440-1843"],"issn-type":[{"value":"1323-7799","type":"print"},{"value":"1440-1843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,21]]}}}