{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T10:48:06Z","timestamp":1790851686988,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,6,21]],"date-time":"2013-06-21T00:00:00Z","timestamp":1371772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Despite significant recent progress in the understanding of idiopathic pulmonary fibrosis (<jats:styled-content style=\"fixed-case\">IPF<\/jats:styled-content>), the early phase of the disease is still poorly understood. We studied patients with <jats:styled-content style=\"fixed-case\">IPF<\/jats:styled-content> without pulmonary function impairment in order to determine the clinical features, natural history and key findings for physiological progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010five patients without pulmonary function impairment were identified from among patients with previously diagnosed <jats:styled-content style=\"fixed-case\">IPF<\/jats:styled-content> who underwent surgical lung biopsies between <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>anuary 1997 and <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ecember 2006 at our institutions. \u2018Without pulmonary function impairment\u2019 was defined as both forced vital capacity (<jats:styled-content style=\"fixed-case\">FVC<\/jats:styled-content>) and diffusing capacity for carbon monoxide (<jats:styled-content style=\"fixed-case\">DLco<\/jats:styled-content>) &gt;80% predicted. Patients diagnosed with <jats:styled-content style=\"fixed-case\">IPF<\/jats:styled-content> through multidisciplinary discussion based on the new <jats:styled-content style=\"fixed-case\">IPF<\/jats:styled-content> guidelines were the subjects of this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixteen patients had a confirmed diagnosis of <jats:styled-content style=\"fixed-case\">IPF<\/jats:styled-content>. Eleven patients presented with chest <jats:styled-content style=\"fixed-case\">X<\/jats:styled-content>\u2010ray abnormality found during an annual health examination. Seven patients were asymptomatic. Eleven patients showed physiological disease progression (median time; 19.9\u2009\u00b1\u200912.3 months) defined by a decline of at least 10% in <jats:styled-content style=\"fixed-case\">FVC<\/jats:styled-content> or at least 15% in <jats:styled-content style=\"fixed-case\">DLco<\/jats:styled-content>. Univariate analysis revealed that both usual interstitial pneumonia pattern and extent of honeycombing on high\u2010resolution computed tomography (HRCT) were factors associated with disease progression (odds ratio 5.634, 95% confidence interval 1.364\u201323.278; odds ratio 2.371\/5%, 95% confidence interval 1.042\u20135.395).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">IPF<\/jats:styled-content> patients without pulmonary function impairment have a progressive but slow clinical course. The existence and extent of honeycombing on <jats:styled-content style=\"fixed-case\">HRCT<\/jats:styled-content> are predictive of disease progression.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12082","type":"journal-article","created":{"date-parts":[[2013,3,14]],"date-time":"2013-03-14T00:59:48Z","timestamp":1363222788000},"page":"820-826","source":"Crossref","is-referenced-by-count":20,"title":["Disease progression in idiopathic pulmonary fibrosis without pulmonary function impairment"],"prefix":"10.1111","volume":"18","author":[{"given":"Yasuhiro","family":"Kondoh","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine and Allergy Tosei General Hospital  Aichi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Allergy Tosei General Hospital  Aichi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Ogura","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Kanagawa Cardiovascular and Respiratory Center  Kanagawa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Johkoh","sequence":"additional","affiliation":[{"name":"Department of Radiology Kinki Central Hospital of Mutual Aid Association of Public School Teachers  Hyogo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiminori","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Department of Radiology Kurume University Hospital Kurume University School of Medicine Center for Diagnostic Imaging  Fukuoka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromitsu","family":"Sumikawa","sequence":"additional","affiliation":[{"name":"Department of Radiology Osaka University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensuke","family":"Kataoka","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Allergy Tosei General Hospital  Aichi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohisa","family":"Baba","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Kanagawa Cardiovascular and Respiratory Center  Kanagawa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas V.","family":"Colby","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Pathology Mayo Clinic  Scottsdale Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Kitaichi","sequence":"additional","affiliation":[{"name":"Department of Pathology National Hospital Organization Kinki\u2010Chuo Chest Medical Center  Osaka 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