{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:43:40Z","timestamp":1777614220638,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,7,25]],"date-time":"2013-07-25T00:00:00Z","timestamp":1374710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Microdebrider bronchoscopy is a relatively new modality for the management of central airway obstruction (<jats:styled-content style=\"fixed-case\">CAO<\/jats:styled-content>) of both benign and malignant origin. Our objective was to describe our experience with this technique, with special attention to its safety and effectiveness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed cases of therapeutic bronchoscopies using microdebrider for <jats:styled-content style=\"fixed-case\">CAO<\/jats:styled-content> from two institutions (<jats:styled-content style=\"fixed-case\">M.D. A<\/jats:styled-content>nderson <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ancer <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>enter and <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ichael <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ebakey <jats:styled-content style=\"fixed-case\">VA M<\/jats:styled-content>edical <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>enter, <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ouston) from August 2008 through February 2012.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 51 cases. Malignant <jats:styled-content style=\"fixed-case\">CAO<\/jats:styled-content> was detected in 36 cases (71%): non\u2010small\u2010cell lung cancer (n\u2009=\u200922), melanoma (n\u2009=\u20093), small\u2010cell\u2010lung cancer (n\u2009=\u20092), thyroid cancer (n\u2009=\u20092), esophageal carcinoma (n\u2009=\u20092), breast cancer (n\u2009=\u20092), and others (n\u2009=\u20093). Benign diseases included: papillomas (n\u2009=\u20098), granulation tissue (n\u2009=\u20093), and others (n\u2009=\u20094). Obstruction was purely endoluminal in 32 cases (63%). Pre\u2010treatment obstruction was severe in 25 cases (49%), moderate in 20 cases (39%) and mild in 6 (12%). Lesions were located in the trachea (n\u2009=\u200923), main stem bronchi (n\u2009=\u200925), and bronchus intermedius (n\u2009=\u20098), with some patients having more than one lesion. After tumor debulking with microdebrider, the residual airway obstruction was insignificant (n\u2009=\u200927 cases; 53%), mild (n\u2009=\u200923 cases; 45%), and moderate (n\u2009=\u20091; 2%). No major complications were encountered, only 2 patients had mild adverse events: one case of pneumomediastinum, and one self\u2010expandable stent damage requiring its removal. Two patients (4%) died within 30 days of causes unrelated to the procedure or the <jats:styled-content style=\"fixed-case\">CAO<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Microdebrider bronchoscopy is a potentially safe and effective way to manage central airway obstruction of both malignant and benign origin.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12087","type":"journal-article","created":{"date-parts":[[2013,3,25]],"date-time":"2013-03-25T06:22:47Z","timestamp":1364192567000},"page":"1011-1015","source":"Crossref","is-referenced-by-count":29,"title":["Safety and effectiveness of microdebrider bronchoscopy for the management of central airway obstruction"],"prefix":"10.1111","volume":"18","author":[{"given":"Roberto F.","family":"Casal","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine The Michael E. DeBakey VA Medical Center Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Iribarren","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine The Michael E. DeBakey VA Medical Center Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Eapen","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Ost","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodolfo","family":"Morice","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlie","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine The Michael E. 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