{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T04:44:59Z","timestamp":1785386699064,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,6,21]],"date-time":"2013-06-21T00:00:00Z","timestamp":1371772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2013,7]]},"abstract":"Abstract<\/jats:title>Background and objective<\/jats:title>The yield of biopsy performed during bronchoscopy is reduced if the lesion is smaller than 30\u2009mm. We evaluated the performance of a new diagnostic technique combining endobronchial ultrasonography with a guide sheath (EBUS\u2010GS<\/jats:styled-content>) and a virtual bronchoscopic navigation system, L<\/jats:styled-content>ungP<\/jats:styled-content>oint (B<\/jats:styled-content>roncus T<\/jats:styled-content>echnologies, I<\/jats:styled-content>nc., M<\/jats:styled-content>ountain V<\/jats:styled-content>iew, CA<\/jats:styled-content>, USA<\/jats:styled-content>), for the diagnosis of small (\u226430\u2009mm) peripheral pulmonary lesions (PPL<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>Between M<\/jats:styled-content>ay 2011 and D<\/jats:styled-content>ecember 2011, we recruited 68 consecutive patients presenting with a PPL<\/jats:styled-content> 30\u2009mm or less in diameter determined by chest computed tomography. We used the L<\/jats:styled-content>ungP<\/jats:styled-content>oint system before bronchoscopy to identify the bronchus into which the bronchoscope should be advanced. We used a thin bronchoscope. EBUS\u2010GS<\/jats:styled-content> was performed using an endoscope ultrasonography system equipped with a 20\u2010MHz<\/jats:styled-content> mechanical radial\u2010type probe. We used a guide sheath with an external diameter of 1.95\u2009mm, thin forceps and brushing.<\/jats:p><\/jats:sec>Results<\/jats:title>The diagnostic yield of the 68 PPL<\/jats:styled-content> was 77.9%; it was 83.7% and 68.0% for the malignant and benign lesions, respectively. Notably, three cases were diagnosed by transbronchial needle\u2010aspiration cytology alone. Univariate and multivariate analyses showed that the EBUS<\/jats:styled-content> probe localization was the most significant contributor to successful diagnosis (diagnostic yield: within vs adjacent to the lesion\u2009=\u200992.1% vs 60.0%, respectively; P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.004 and P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.003, respectively).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The combination of EBUS\u2010GS<\/jats:styled-content> and L<\/jats:styled-content>ungP<\/jats:styled-content>oint was useful for diagnosing small PPL<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12095","type":"journal-article","created":{"date-parts":[[2013,4,16]],"date-time":"2013-04-16T07:18:38Z","timestamp":1366096718000},"page":"834-839","source":"Crossref","is-referenced-by-count":59,"title":["Diagnostic yield of combined bronchoscopy and endobronchial ultrasonography, under L<\/scp>ungP<\/scp>oint guidance for small peripheral pulmonary lesions"],"prefix":"10.1111","volume":"18","author":[{"given":"Motohiro","family":"Tamiya","sequence":"first","affiliation":[{"name":"Department of Thoracic Malignancy Osaka Prefectural Medical Center for Respiratory and Allergic Diseases Osaka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Thoracic Malignancy Osaka Prefectural Medical Center for Respiratory and Allergic Diseases Osaka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Sasada","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology, Respiratory Endoscopy Division National Cancer Center Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Shiroyama","sequence":"additional","affiliation":[{"name":"Department of Thoracic Malignancy Osaka Prefectural Medical Center for Respiratory and Allergic Diseases Osaka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Morishita","sequence":"additional","affiliation":[{"name":"Department of Thoracic Malignancy Osaka Prefectural Medical Center for Respiratory and Allergic Diseases Osaka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidekazu","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Thoracic Malignancy Osaka Prefectural Medical Center for Respiratory and Allergic Diseases Osaka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emi","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Radiology Osaka Prefectural Medical Center for Respiratory and Allergic Diseases Osaka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomonori","family":"Hirashima","sequence":"additional","affiliation":[{"name":"Department of Thoracic Malignancy Osaka Prefectural Medical Center for Respiratory and Allergic Diseases Osaka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunimitu","family":"Kawahara","sequence":"additional","affiliation":[{"name":"Department of Pathology Osaka Prefectural Hospital Organization Osaka Prefectural Medical Center for Respiratory and Allergic Diseases Osaka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Kawase","sequence":"additional","affiliation":[{"name":"Department of Thoracic Malignancy Osaka Prefectural Medical Center for Respiratory and Allergic Diseases Osaka"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,6,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200202-070SO"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.201.3.8939234"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0909530"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70364-X"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70232-7"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.126.3.959"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.5.3551"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.3.1761"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.130.2.559"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.5.3551"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00032001"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.50.4275"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3181e8b308"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-2506"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0007-0971(81)90003-6"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.68.1.12"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.175.1.1750239"},{"key":"e_1_2_7_19_1","first-page":"701","article-title":"Bronchoscopic 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