{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T15:46:05Z","timestamp":1789832765069,"version":"4.0.1"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,7,25]],"date-time":"2013-07-25T00:00:00Z","timestamp":1374710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Diseases associated with laryngeal dysfunction include chronic refractory cough (<jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content>), paradoxical vocal fold movement (<jats:styled-content style=\"fixed-case\">PVFM<\/jats:styled-content>), muscle tension dysphonia (<jats:styled-content style=\"fixed-case\">MTD<\/jats:styled-content>) and globus pharyngeus. We hypothesized the presence of a common sensory laryngeal dysfunction, the \u2018laryngeal hypersensitivity\u2019 syndrome, in these conditions. The aim of the study was to compare symptoms and sensory function in patients with <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">PVFM<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">MTD<\/jats:styled-content> and globus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The 103 participants included healthy controls (<jats:italic>n<\/jats:italic>\u2009=\u200913) and four case groups: <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u2009=\u200933), <jats:styled-content style=\"fixed-case\">PVFM<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u2009=\u200928), globus pharyngeus (<jats:italic>n<\/jats:italic>\u2009=\u200911) and <jats:styled-content style=\"fixed-case\">MTD<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u2009=\u200918). Participants completed self\u2010report questionnaires: <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ymptom <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>requency and <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>everity <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>cale, <jats:styled-content style=\"fixed-case\">V<\/jats:styled-content>oice <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>andicap <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>ndex and the <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>aryngeal <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>araesthesia <jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>uestionnaire; and quantitative sensory testing: capsaicin cough reflex sensitivity, hypertonic saline challenge, the timed swallow test, acoustic voice testing, cough frequency monitor and a voice stress test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All case groups reported a high\u2010symptom burden in comparison to controls. The case groups showed a similar pattern of symptoms, with impairment in each of the cough, respiration, vocal and upper airway symptom domains. Objective testing revealed significant sensory impairment in the case groups compared to controls and also showed an overlap in sensory dysfunction between the four case groups. Furthermore, there was cross\u2010sensory stimulation of symptoms whereby stimulation of a particular response resulted in symptoms in another domain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These discrete clinical laryngeal syndromes display considerable overlap in their clinical features and a common sensory dysfunction, supporting the \u2018laryngeal hypersensitivity\u2019 hypothesis. Reconceptualizing functional laryngeal disorders as a form of laryngeal hypersensitivity syndrome provides an alternative approach to management of these perplexing conditions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12103","type":"journal-article","created":{"date-parts":[[2013,4,26]],"date-time":"2013-04-26T07:15:21Z","timestamp":1366960521000},"page":"948-956","source":"Crossref","is-referenced-by-count":112,"title":["Laryngeal sensory dysfunction in laryngeal hypersensitivity syndrome"],"prefix":"10.1111","volume":"18","author":[{"given":"Anne E.","family":"Vertigan","sequence":"first","affiliation":[{"name":"Priority Centre for Asthma and Respiratory Diseases School of Medicine and Public Health The University of Newcastle"},{"name":"Speech Pathology Department"},{"name":"Hunter Medical Research Institute  Newcastle"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah L.","family":"Bone","sequence":"additional","affiliation":[{"name":"Speech Pathology Department"},{"name":"Hunter Medical Research Institute  Newcastle"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter G.","family":"Gibson","sequence":"additional","affiliation":[{"name":"Priority Centre for Asthma and Respiratory Diseases School of Medicine and Public Health The University of Newcastle"},{"name":"Department of Respiratory and Sleep Medicine"},{"name":"Hunter Medical Research Institute  Newcastle"},{"name":"Woolcock Institute of Medical Research  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,7,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2005.12.008"},{"issue":"2","key":"e_1_2_6_3_1","first-page":"A48","article-title":"Cough reflex hypersensitivity and upper airway hyperresponsiveness in vocal cord dysfunction with chronic cough","volume":"11","author":"Ryan N","year":"2006","journal-title":"Respirology"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-1997(00)80016-8"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-1997(99)80049-6"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940511400401"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.064337"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2011.01.005"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00020840-200006000-00007"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-1997(97)80011-2"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00057407"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1983.tb09716.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.9.822"},{"key":"e_1_2_6_14_1","volume-title":"Dysphagia: Clinical Management in Adults and Children","author":"Groher M","year":"2010"},{"key":"e_1_2_6_15_1","volume-title":"Voice and Articulation Drill Book","author":"Fairbanks G","year":"1960"},{"key":"e_1_2_6_16_1","article-title":"Spirometry: the measurement and interpretation of ventilatory function in clinical practice","author":"Pierce R","year":"1995","journal-title":"Thorac. 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