{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:34:30Z","timestamp":1787315670329,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,9,23]],"date-time":"2013-09-23T00:00:00Z","timestamp":1379894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2013,10]]},"abstract":"Abstract<\/jats:title>\n \n Background and objective<\/jats:title>\n \n To explore the effect of long\u2010term therapy with azithromycin in regards to airway oxidative stress markers in exhaled breath condensate (\n EBC<\/jats:styled-content>\n ) of adult patients with stable non\u2010cystic fibrosis (\n CF<\/jats:styled-content>\n ) bronchiectasis.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Open\u2010label prospective study of 30 patients randomized to azithromycin 250\u2009mg three times per week during 3 months (16 patients) or control (14 patients). Primary outcome were changes in nitric oxide, 8\u2010isoprostane,\n pH<\/jats:styled-content>\n , nitrites and nitrates in\n EBC<\/jats:styled-content>\n . Secondary outcomes were changes in exacerbation rates, dyspnoea (\n B<\/jats:styled-content>\n org scale), sputum volume (cc), sputum colour (15\u2010point scale), bacterial infection, health\u2010related quality of life (\n S<\/jats:styled-content>\n t\n G<\/jats:styled-content>\n eorge's\n R<\/jats:styled-content>\n espiratory\n Q<\/jats:styled-content>\n uestionnaire), lung function and radiological extension.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Azithromycin produced a significant decrease in sputum volume (8.9 (1.8) mL vs 2.1 (3.4) mL) and number of exacerbations (0.1 (0.6) vs 1.2 (0.9)). Dyspnoea (0.4 (0.1) vs 0.1 (0.2)) and health\u2010related quality of life also improved after therapy. However, oxidative stress markers in\n EBC<\/jats:styled-content>\n , systemic inflammatory markers as well as functional respiratory tests did not differ from the control group after therapy. A post\u2010hoc analysis comparing patients infected or not with\n \n P<\/jats:styled-content>\n seudomonas aeruginosa\n <\/jats:italic>\n revealed that these effects were more pronounced in infected patients. In this subgroup, treatment was followed by a significant reduction in sputum volume, number of exacerbations, dyspnoea and\n S<\/jats:styled-content>\n t\n G<\/jats:styled-content>\n eorge's\n R<\/jats:styled-content>\n espiratory\n Q<\/jats:styled-content>\n uestionnaire total score. Of all airway oxidative stress markers, only nitrates in\n EBC<\/jats:styled-content>\n were reduced after therapy.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Long\u2010term azythromicin treatment has some clinical benefits in patients with non\u2010\n CF<\/jats:styled-content>\n stable bronchiectasis, but it does not affect airway oxidative stress markers.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/resp.12130","type":"journal-article","created":{"date-parts":[[2013,5,29]],"date-time":"2013-05-29T07:02:55Z","timestamp":1369810975000},"page":"1056-1062","source":"Crossref","is-referenced-by-count":34,"title":["Effects of long\u2010term azithromycin therapy on airway oxidative stress markers in non\u2010cystic fibrosis bronchiectasis"],"prefix":"10.1111","volume":"18","author":[{"given":"Afredo De","family":"Diego","sequence":"first","affiliation":[{"name":"Department of Pneumology University Hospital La Fe Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Milara","sequence":"additional","affiliation":[{"name":"Foundation for Investigation Consorcio University General Hospital (CHGU) Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Martinez\u2010Morag\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Neumolog\u00eda Hospital of Sagunto Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Palop","sequence":"additional","affiliation":[{"name":"CIBERes Carlos III Health Institute Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montse","family":"Le\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Pneumology University Hospital La Fe Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Cortijo","sequence":"additional","affiliation":[{"name":"Foundation for Investigation Consorcio University General Hospital (CHGU) Valencia Spain"},{"name":"CIBERes Carlos III Health Institute Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,9,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra012519"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00069007"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.158.1.9707096"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.53.8.680"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200111-068OC"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.158.3.9710031"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2008.12.004"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000106377"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.1999.13b24.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.122.1.213"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.57.3.212"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.057950"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0954-6111(03)00042-8"},{"key":"e_1_2_7_15_1","first-page":"540","article-title":"Prophylactic antibiotic treatment of bronchiectasis with azithromycin","volume":"59","author":"Davies G","year":"2004","journal-title":"Thorax"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2008.06.005"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.2165\/00151829-200504020-00005"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60953-2"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1104623"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.2290"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.1937"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.125.2_suppl.70S"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.125.2_suppl.41S"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.2000.15a12.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.179.3.2027992"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1579-2129(06)60410-2"},{"key":"e_1_2_7_27_1","first-page":"538","article-title":"Validation of the St. George's Respiratory Questionnaires in bronchiectasis","volume":"158","author":"Wilson CB","year":"1997","journal-title":"Am. 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