{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:19:07Z","timestamp":1787015947352,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,9,23]],"date-time":"2013-09-23T00:00:00Z","timestamp":1379894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2013,10]]},"abstract":"Abstract<\/jats:title>\n \n Background and objective<\/jats:title>\n \n The use of continuous positive airway pressure (\n CPAP<\/jats:styled-content>\n ) treatment in patients with obesity hypoventilation syndrome (\n OHS<\/jats:styled-content>\n ) and obstructive sleep apnoea (\n OSA<\/jats:styled-content>\n ) was evaluated, and factors that might predict\n CPAP<\/jats:styled-content>\n treatment failure were determined.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A sleep study was performed in 29 newly diagnosed, clinically stable\n OHS<\/jats:styled-content>\n patients.\n CPAP<\/jats:styled-content>\n treatment was commenced if the apnoea\u2013hypopnoea index was >15. Lung function, night\u2010time oximetry, blood adipokine and\n C<\/jats:styled-content>\n \u2010reactive protein levels were assessed prospectively on enrollment and after 3 months. Treatment failure at 3 months was defined as daytime arterial partial pressure of carbon dioxide (\n \n PaCO\n 2<\/jats:sub>\n <\/jats:styled-content>\n ) >45\u2009\n mm\u2009Hg<\/jats:styled-content>\n and\/or oxygen saturation (\n \n SpO\n 2<\/jats:sub>\n <\/jats:styled-content>\n ) <90% for >30% of the night\u2010time oximetry study.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n All patients had severe\n OSA<\/jats:styled-content>\n (median apnoea\u2013hypopnoea index\u2009=\u200974.7 (62\u2013100) with a nocturnal mean\n \n SpO\n 2<\/jats:sub>\n <\/jats:styled-content>\n of 81.4\u2009\u00b1\u20097), and all patients were treated with\n CPAP<\/jats:styled-content>\n . The percentage of time spent below 90% saturation improved from 8.4% (0.0\u201339.0%) to 0.3% (0.4\u20134.0%). Awake\n \n PaCO\n 2<\/jats:sub>\n <\/jats:styled-content>\n decreased from 50 (47\u201353)\n mm\u2009Hg<\/jats:styled-content>\n to 43 (40\u201345)\n mm\u2009Hg<\/jats:styled-content>\n . Seven patients failed\n CPAP<\/jats:styled-content>\n treatment after 3 months.\n \n PaCO\n 2<\/jats:sub>\n <\/jats:styled-content>\n at 1 month and mean night\u2010time\n \n SpO\n 2<\/jats:sub>\n <\/jats:styled-content>\n during the first night of optimal\n CPAP<\/jats:styled-content>\n were associated with treatment failure at 3 months (odds ratio 1.4 (1.03\u20131.98);\n \n P<\/jats:styled-content>\n <\/jats:italic>\n \u2009=\u20090.034 and 0.6 (0.34\u20130.93);\n \n P<\/jats:styled-content>\n <\/jats:italic>\n \u2009=\u20090.027).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n CPAP<\/jats:styled-content>\n treatment improves night\u2010time oxygenation and daytime hypoventilation in selected clinically stable\n OHS<\/jats:styled-content>\n patients who also have\n OSA<\/jats:styled-content>\n . Patients with worse night\u2010time saturation while on\n CPAP<\/jats:styled-content>\n and higher daytime\n \n PaCO\n 2<\/jats:sub>\n <\/jats:styled-content>\n at 1 month were more likely to fail\n CPAP<\/jats:styled-content>\n treatment.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/resp.12131","type":"journal-article","created":{"date-parts":[[2013,5,29]],"date-time":"2013-05-29T07:02:55Z","timestamp":1369810975000},"page":"1135-1142","source":"Crossref","is-referenced-by-count":44,"title":["Continuous positive airway pressure in clinically stable patients with mild\u2010to\u2010moderate obesity hypoventilation syndrome and obstructive sleep apnoea"],"prefix":"10.1111","volume":"18","author":[{"given":"Neus","family":"Salord","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Hospital de la Santa Creu i Sant Pau Barcelona Spain"},{"name":"Respiratory Diseases Research Network (CibeRes) Universitat Aut\u00f2noma de Barcelona Barcelona Spain"},{"name":"Department of Internal Medicine, School of Medicine Universitat Aut\u00f2noma de Barcelona Barcelona Spain"},{"name":"Department of Respiratory Medicine Hospital Universitari de Bellvitge Hospitalet de LLobregat Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Mayos","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Hospital de la Santa Creu i Sant Pau Barcelona Spain"},{"name":"Respiratory Diseases Research Network (CibeRes) Universitat Aut\u00f2noma de Barcelona Barcelona Spain"},{"name":"Department of Internal Medicine, School of Medicine Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa Maria","family":"Miralda","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Hospital de la Santa Creu i Sant Pau Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariadna","family":"Farr\u00e9","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Hospital de la Santa Creu i Sant Pau Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Carreras","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Hospital de la Santa Creu i Sant Pau Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Sust","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Hospital de la Santa Creu i Sant Pau Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Masuet\u2010Aumatell","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Hospital Universitari de Bellvitge Hospitalet de LLobregat Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Hospital de la Santa Creu i Sant Pau Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition Hospital de la Santa Creu i Sant Pau Barcelona Spain"},{"name":"Reseach network for diabetes and Metabolic Diseases CIBERDEM Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,9,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyi272"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2007.086843"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.284.23.3015"},{"key":"e_1_2_7_5_1","first-page":"1347","article-title":"Obesity hypoventilation syndrome: a state\u2010of\u2010the\u2010art\u2010review","volume":"55","author":"Mokhlesi B","year":"2010","journal-title":"Respir. 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