{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T22:12:27Z","timestamp":1791670347499,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,10,28]],"date-time":"2013-10-28T00:00:00Z","timestamp":1382918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2013,11]]},"abstract":"Abstract<\/jats:title>\n \n Background and objective<\/jats:title>\n \n The objective of this study was to evaluate the long\u2010term cardiovascular mortality in patients with severe obstructive sleep apnoea (\n OSA<\/jats:styled-content>\n ) treated with either continuous positive airway pressure (\n CPAP<\/jats:styled-content>\n ) or mandibular advancing device (\n MAD<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A non\u2010concurrent cohort study of 570 subjects with severe\n OSA<\/jats:styled-content>\n (apnoea\/hypopnoea index (\n AHI<\/jats:styled-content>\n )\u2009\u2265\u200930\/h) and a control group of 269 subjects (\n AHI<\/jats:styled-content>\n \u2009<\u20095\/h) were followed up for a median of 79 months (interquartile range 76\u201388 months). All patients received\n CPAP<\/jats:styled-content>\n initially.\n MAD<\/jats:styled-content>\n was offered for those who were non\u2010adherent to\n CPAP<\/jats:styled-content>\n . The endpoint was cardiovascular death.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n \u2003Two hundred and eight control subjects, 177 patients treated with\n CPAP<\/jats:styled-content>\n , 72 with\n MAD<\/jats:styled-content>\n and 212 who declined treatment were analysed. Forty\u2010two patients had a fatal cardiovascular event during the course of the study. The non\u2010apnoeic group had the lowest cardiovascular death rate (0.28 per 100 person\u2010years (95% confidence interval (\n CI<\/jats:styled-content>\n ): 0.08\u20130.71)) followed by the\n CPAP<\/jats:styled-content>\n \u2010treated (0.56 per 100 person\u2010years (95%\n CI<\/jats:styled-content>\n : 0.20\u20131.23)) and the\n MAD<\/jats:styled-content>\n \u2010treated\n OSA<\/jats:styled-content>\n group (0.61 per 100 person\u2010years (95%\n CI<\/jats:styled-content>\n : 0.13\u20131.78)), with the highest cardiovascular mortality rate observed in the untreated\n OSA<\/jats:styled-content>\n group (2.1 per 100 person\u2010years (95%\n CI<\/jats:styled-content>\n : 1.37\u20132.92)). Although residual\n AHI<\/jats:styled-content>\n for\n MAD<\/jats:styled-content>\n \u2010treated patients was significantly higher than\n CPAP<\/jats:styled-content>\n \u2010treated patients (16.3\u2009\u00b1\u20095.1\/h vs. 4.5\u2009\u00b1\u20092.3\/h;\n \n P<\/jats:styled-content>\n <\/jats:italic>\n \u2009<\u20090.001), there was no difference in cardiovascular death rate between the two groups (hazard ratio 1.08 (95%\n CI<\/jats:styled-content>\n : 0.55\u20131.74);\n \n P<\/jats:styled-content>\n <\/jats:italic>\n \u2009=\u20090.71).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Both\n CPAP<\/jats:styled-content>\n and\n MAD<\/jats:styled-content>\n may be equally effective therapy in reducing the risk of fatal cardiovascular events in patients with severe\n OSA<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/resp.12140","type":"journal-article","created":{"date-parts":[[2013,6,3]],"date-time":"2013-06-03T09:13:16Z","timestamp":1370250796000},"page":"1184-1190","source":"Crossref","is-referenced-by-count":127,"title":["Cardiovascular mortality in obstructive sleep apnoea treated with continuous positive airway pressure or oral appliance: An observational study"],"prefix":"10.1111","volume":"18","author":[{"given":"Anil","family":"Anandam","sequence":"first","affiliation":[{"name":"Division of Pulmonary, Critical Care, and Sleep Medicine Department of Medicine Department of Social and Preventive Medicine Western New York Respiratory Research Center Buffalo New York USA"},{"name":"School of Medicine and Biomedical Sciences School of Public Health and Health Professions State University of New York at Buffalo Buffalo New York 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Jaoude","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care, and Sleep Medicine Department of Medicine Department of Social and Preventive Medicine Western New York Respiratory Research Center Buffalo New York USA"},{"name":"School of Medicine and Biomedical Sciences School of Public Health and Health Professions State University of New York at Buffalo Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali A.","family":"El\u2010Solh","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care, and Sleep Medicine Department of Medicine Department of Social and Preventive Medicine Western New York Respiratory Research Center Buffalo New York USA"},{"name":"School of Medicine and Biomedical Sciences School of Public Health and Health Professions State University of New York at Buffalo Buffalo New York 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