{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T11:29:59Z","timestamp":1789039799477,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,12,15]],"date-time":"2013-12-15T00:00:00Z","timestamp":1387065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2014,4]]},"abstract":"Abstract<\/jats:title>Background and objective<\/jats:title>Previous studies suggested that chronic nasal symptoms (CNS<\/jats:styled-content>) are frequent in chronic obstructive pulmonary disease (COPD<\/jats:styled-content>) subjects, but their contribution to dyspnoea and quality\u2010of\u2010life (QoL<\/jats:styled-content>) impairment is not clearly established.<\/jats:p><\/jats:sec>Methods<\/jats:title>Data from the F<\/jats:styled-content>rench COPD<\/jats:styled-content> cohort \u2018Initiatives bronchopneumopathie chronique obstructive\u2019 were analyzed to assess the frequency of CNS<\/jats:styled-content> (rhinorrhea, obstruction, anosmia) in COPD<\/jats:styled-content> patients and analyze their impact and associated risk factors. Univariate and multivariate analyses were performed to assess the relationship between CNS<\/jats:styled-content> with sociodemographic and anthropometric characteristics, risk factors, respiratory symptoms, spirometry, QoL<\/jats:styled-content> (S<\/jats:styled-content>aint G<\/jats:styled-content>eorge's respiratory questionnaire (SGRQ<\/jats:styled-content>)), dyspnoea (modified M<\/jats:styled-content>edical R<\/jats:styled-content>esearch C<\/jats:styled-content>ouncil (mMRC<\/jats:styled-content>) scale), mood disorders (H<\/jats:styled-content>ospital A<\/jats:styled-content>nxiety and D<\/jats:styled-content>epression S<\/jats:styled-content>cale (HADS<\/jats:styled-content>)), number of exacerbations and comorbid conditions.<\/jats:p><\/jats:sec>Results<\/jats:title>CNS<\/jats:styled-content> were reported by 115 of 274 COPD<\/jats:styled-content> subjects (42%). Among them, rhinorrhea and nasal obstruction were reported by 62% and 43%, respectively. In multivariate analysis, COPD<\/jats:styled-content> patients with CNS<\/jats:styled-content> had higher SGRQ<\/jats:styled-content> total scores, corresponding to worse QoL<\/jats:styled-content> (P<\/jats:italic>\u2009=\u20090.01), while no independent association was found with exacerbations, lung function and HADS<\/jats:styled-content>. Among SGRQ<\/jats:styled-content> domains, an independent association was found with the activity score (P<\/jats:italic>\u2009=\u20090.007). When SGRQ<\/jats:styled-content> score was forced out of the model to avoid redundancy, mMRC<\/jats:styled-content> score was independently associated with CNS<\/jats:styled-content> (P<\/jats:italic>\u2009=\u20090.01). Among risk factors, cumulative smoking, hay fever and atopic dermatitis but not occupational exposures were independently associated with CNS<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>In this group of COPD<\/jats:styled-content> subjects, CNS<\/jats:styled-content> were frequently observed and associated with dyspnoea and poorer QoL<\/jats:styled-content>. CNS<\/jats:styled-content> should be systematically assessed and could be a potential target in the management of COPD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12224","type":"journal-article","created":{"date-parts":[[2013,12,16]],"date-time":"2013-12-16T02:22:40Z","timestamp":1387160560000},"page":"346-352","source":"Crossref","is-referenced-by-count":15,"title":["Association of chronic nasal symptoms with dyspnoea and quality\u2010of\u2010life impairment in chronic obstructive pulmonary disease"],"prefix":"10.1111","volume":"19","author":[{"given":"Denis","family":"Caillaud","sequence":"first","affiliation":[{"name":"Pulmonary Department Gabriel Montpied University Hospital Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Chanez","sequence":"additional","affiliation":[{"name":"Pulmonary Department APHM, INSERM U1077 CNRS UMR 7733 Aix Marseille Universit\u00e9 Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Escamilla","sequence":"additional","affiliation":[{"name":"Pulmonary Department Larrey University Hospital Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre\u2010R\u00e9gis","family":"Burgel","sequence":"additional","affiliation":[{"name":"Respiratory and Intensive Care Medicine Cochin\u2010Broca\u2010H\u00f4tel\u2010Dieu Hospital Group AP\u2010HP and Paris Descartes University Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Court\u2010Fortune","sequence":"additional","affiliation":[{"name":"Pulmonary Department University Hospital Saint\u2010Etienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Nesme\u2010Meyer","sequence":"additional","affiliation":[{"name":"Pulmonary Department La Croix Rousse University Hospital Lyon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00ebtan","family":"Deslee","sequence":"additional","affiliation":[{"name":"Pulmonary Department Maison Blanche University Hospital Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Perez","sequence":"additional","affiliation":[{"name":"Pulmonary Department Albert Calmette University Hospital Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Pinet","sequence":"additional","affiliation":[{"name":"Polyclinique Les Fleurs Pneumologie Ollioules France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Roche","sequence":"additional","affiliation":[{"name":"Respiratory and Intensive Care Medicine Cochin\u2010Broca\u2010H\u00f4tel\u2010Dieu Hospital Group AP\u2010HP and Paris Descartes University Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Initiatives BPCO scientific committee and investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.01.17405960"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/0036554021000028071"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.01054.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2011.25.3556"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01620.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70464-1"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01892.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01545.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2008.112862"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2003.006650"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0954-6111(03)00114-8"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2004.01.010"},{"key":"e_1_2_7_14_1","first-page":"107","article-title":"Rhinosinusitis in COPD: symptoms, mucosal changes, nasal lavage cells and eicosanoids","volume":"5","author":"Piotrowska VM","year":"2011","journal-title":"Int. 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