{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T10:58:05Z","timestamp":1792061885277,"version":"4.4.0"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,1,3]],"date-time":"2014-01-03T00:00:00Z","timestamp":1388707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2014,2]]},"abstract":"Abstract<\/jats:title>\n \n Peripheral venous blood gas (\n PVBG<\/jats:styled-content>\n ) analysis is increasingly being used as a substitute for arterial blood sampling; however, comparability has not been clearly established. To determine if the\n pH<\/jats:styled-content>\n ,\n \n \n PCO\n 2<\/jats:sub>\n <\/jats:roman>\n <\/jats:styled-content>\n and\n \n \n PO\n 2<\/jats:sub>\n <\/jats:roman>\n <\/jats:styled-content>\n obtained from\n PVBG<\/jats:styled-content>\n analysis is comparable with arterial blood gas (\n ABG<\/jats:styled-content>\n ) analysis. A search was conducted of electronic databases as well as hand\u2010searching of journals and reference lists through\n D<\/jats:styled-content>\n ecember 2012 to identify studies comparing\n PVBG<\/jats:styled-content>\n with\n ABG<\/jats:styled-content>\n analysis in adult subjects. A systematic review was conducted in accordance with the\n P<\/jats:styled-content>\n referred\n R<\/jats:styled-content>\n eporting\n I<\/jats:styled-content>\n tems for\n S<\/jats:styled-content>\n ystematic\n R<\/jats:styled-content>\n eviews and\n M<\/jats:styled-content>\n eta\u2010\n A<\/jats:styled-content>\n nalyses statement. A meta\u2010analysis using a random effects model was used to calculate the average difference (bias) and the limits of agreement for the venous and arterial\n pH<\/jats:styled-content>\n ,\n \n \n PCO\n 2<\/jats:sub>\n <\/jats:roman>\n <\/jats:styled-content>\n and\n \n \n PO\n 2<\/jats:sub>\n <\/jats:roman>\n <\/jats:styled-content>\n . A total of 18 studies comprising 1768 subjects were included in the meta\u2010analysis. There was considerable heterogeneity between studies with\n I<\/jats:styled-content>\n 2<\/jats:sup>\n approaching 100%. There was little difference between the\n pH<\/jats:styled-content>\n obtained from the\n PVBG<\/jats:styled-content>\n and the\n ABG<\/jats:styled-content>\n , with the arterial\n pH<\/jats:styled-content>\n typically 0.03 higher than the venous\n pH<\/jats:styled-content>\n (95% confidence interval 0.029\u20130.038). The venous and arterial\n \n \n PCO\n 2<\/jats:sub>\n <\/jats:roman>\n <\/jats:styled-content>\n were not comparable because the 95% prediction interval of the bias for venous\n \n \n PCO\n 2<\/jats:sub>\n <\/jats:roman>\n <\/jats:styled-content>\n was unacceptably wide, extending from \u221210.7\u2009mm\u2009Hg to +2.4\u2009mm\u2009Hg. The\n \n \n PO\n 2<\/jats:sub>\n <\/jats:roman>\n <\/jats:styled-content>\n values compared poorly, the arterial\n \n \n PO\n 2<\/jats:sub>\n <\/jats:roman>\n <\/jats:styled-content>\n typically 36.9\u2009mm\u2009Hg greater than the venous with significant variability (95% confidence interval from 27.2 to 46.6\u2009mm\u2009\n H<\/jats:styled-content>\n g).\n PVBG<\/jats:styled-content>\n analysis compares well with\n ABG<\/jats:styled-content>\n analysis for\n pH<\/jats:styled-content>\n estimations in adults but not to the\n \n \n PCO\n 2<\/jats:sub>\n <\/jats:roman>\n <\/jats:styled-content>\n or\n \n \n PO\n 2<\/jats:sub>\n <\/jats:roman>\n <\/jats:styled-content>\n . These differences are sufficiently large to be of clinical significance.\n <\/jats:p>","DOI":"10.1111\/resp.12225","type":"journal-article","created":{"date-parts":[[2014,1,3]],"date-time":"2014-01-03T04:19:48Z","timestamp":1388722788000},"page":"168-175","source":"Crossref","is-referenced-by-count":148,"title":["Peripheral venous and arterial blood gas analysis in adults: are they comparable? 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