{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:38:17Z","timestamp":1791517097379,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,12,26]],"date-time":"2013-12-26T00:00:00Z","timestamp":1388016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Rheumatoid arthritis\u2010associated interstitial lung disease (<jats:styled-content style=\"fixed-case\">RA\u2010ILD<\/jats:styled-content>) has a heterogeneous clinical presentation and disease course. Establishing prognosis for these patients is challenging. Identifying the factors that predict mortality in patients with <jats:styled-content style=\"fixed-case\">RA\u2010ILD<\/jats:styled-content> could help guide management. A detailed systematic review was conducted in order to identify individual variables that predict mortality in <jats:styled-content style=\"fixed-case\">RA\u2010ILD<\/jats:styled-content>. A literature review was performed using keywords and medical subject headings to identify all articles relating to the prognosis of <jats:styled-content style=\"fixed-case\">RA\u2010ILD<\/jats:styled-content>. Studies were included if they identified predictors of mortality in adults with <jats:styled-content style=\"fixed-case\">RA\u2010ILD<\/jats:styled-content>, were published in <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>nglish, and included at least 10 patients with <jats:styled-content style=\"fixed-case\">RA\u2010ILD<\/jats:styled-content>. Two authors independently reviewed each citation and extracted data from all studies meeting inclusion criteria. Any differences were then resolved by consensus. A total of 10 studies met our inclusion criteria. All were observational cohort studies of variable quality. Mean age of reported patients ranged from 55 to 69 years, and 41.7% of all patients were male. Median survival ranged from 3.2 to 8.1 years. Significant predictors of mortality on multivariate analysis were older age, male gender, lower diffusion capacity for carbon monoxide, extent of fibrosis, and the presence of usual interstitial pneumonia pattern. Mortality in <jats:styled-content style=\"fixed-case\">RA\u2010ILD<\/jats:styled-content> is associated with several patient\u2010 and <jats:styled-content style=\"fixed-case\">ILD<\/jats:styled-content>\u2010specific variables; however, previous studies are of low quality.<\/jats:p>","DOI":"10.1111\/resp.12234","type":"journal-article","created":{"date-parts":[[2013,12,26]],"date-time":"2013-12-26T10:02:52Z","timestamp":1388052172000},"page":"493-500","source":"Crossref","is-referenced-by-count":169,"title":["Predictors of mortality in rheumatoid arthritis\u2010related interstitial lung disease"],"prefix":"10.1111","volume":"19","author":[{"given":"Deborah","family":"Assayag","sequence":"first","affiliation":[{"name":"Department of Medicine University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly","family":"Lubin","sequence":"additional","affiliation":[{"name":"Department of Medicine University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce S.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talmadge E.","family":"King","sequence":"additional","affiliation":[{"name":"Department of Medicine University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harold R.","family":"Collard","sequence":"additional","affiliation":[{"name":"Department of Medicine University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Ryerson","sequence":"additional","affiliation":[{"name":"Department of Medicine University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-857X(05)70201-5"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27405"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/931342"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201004-0622OC"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200703-045MS"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-0444"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.127.6.2019"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.120626"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00092309"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2012.04.004"},{"key":"e_1_2_6_12_1","first-page":"A3031","article-title":"Prognostic significance of histopahotlogic and radiographic pattern in interstitial lung disease associated with rheumatoid arthritis","volume":"183","author":"Nakamura Y","year":"2011","journal-title":"Am. 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