{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T14:02:30Z","timestamp":1749132150567},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,2,11]],"date-time":"2014-02-11T00:00:00Z","timestamp":1392076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Xenon ventilation computed tomography (<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>) has shown potential in assessing the regional ventilation status in subjects with asthma. The purpose of this study was to evaluate the usefulness of xenon ventilation <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> in the management of asthma in the elderly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Treatment\u2010na\u00efve asthmatics aged 65 years or older were recruited. Before initiation of medication, spirometry with bronchodilator (<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>) reversibility, questionnaires to assess the severity of symptoms including a visual analogue scale (<jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content>), tests to evaluate cognitive function and mood, and xenon ventilation <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> were performed. Xenon gas trapping (<jats:styled-content style=\"fixed-case\">XT<\/jats:styled-content>) on xenon ventilation <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> represents an area where inhaled xenon gas was not expired and was trapped. Symptoms and lung functions were measured again after the 12\u2010week treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 30 elderly asthmatics were enrolled. The severity of dyspnoea measured by the <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content> showed a significant correlation with the total number of areas of <jats:styled-content style=\"fixed-case\">XT<\/jats:styled-content> on the xenon ventilation <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> taken in the pre\u2010<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> wash\u2010out phase (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.723, <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009&lt;\u20090.001). The total number of areas of <jats:styled-content style=\"fixed-case\">XT<\/jats:styled-content> significantly decreased after <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> inhalation, and differences in the total number of areas of <jats:styled-content style=\"fixed-case\">XT<\/jats:styled-content> (between the pre\u2010 and post\u2010<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> wash\u2010out phases) at baseline showed significant correlations with the per cent increases in forced expiratory volume in 1\u2009s after subsequent anti\u2010asthma treatment (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.775, <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Xenon ventilation <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> may be an objective and promising tool in the measurement of dyspnoea and prediction of the treatment response in elderly asthmatics.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12242","type":"journal-article","created":{"date-parts":[[2014,2,12]],"date-time":"2014-02-12T10:56:11Z","timestamp":1392202571000},"page":"389-395","source":"Crossref","is-referenced-by-count":12,"title":["Xenon ventilation computed tomography and the management of asthma in the elderly"],"prefix":"10.1111","volume":"19","author":[{"given":"Heung\u2010Woo","family":"Park","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Seoul National University College of Medicine  Seoul Korea"},{"name":"Institute of Allergy and Clinical Immunology Seoul National University Medical Research Center  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae\u2010Woo","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University College of Medicine  Seoul Korea"},{"name":"Institute of Allergy and Clinical Immunology Seoul National University Medical Research Center  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung\u2010Mook","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University College of Medicine  Seoul Korea"},{"name":"Institute of Allergy and Clinical Immunology Seoul National University Medical Research Center  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae\u2010Wan","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University College of Medicine  Seoul Korea"},{"name":"Institute of Allergy and Clinical Immunology Seoul National University Medical Research Center  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"So\u2010Hee","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University College of Medicine  Seoul Korea"},{"name":"Institute of Allergy and Clinical Immunology Seoul National University Medical Research Center  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang Hyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiology Seoul National University College of Medicine  Seoul Korea"},{"name":"Institute of Radiation Medicine Seoul National University Medical Research Center  Seoul Korea"},{"name":"Seoul National University Hospital Healthcare Gangnam Center  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Mo","family":"Goo","sequence":"additional","affiliation":[{"name":"Department of Radiology Seoul National University College of Medicine  Seoul Korea"},{"name":"Institute of Radiation Medicine Seoul National University Medical Research Center  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung\u2010Up","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University College of Medicine  Seoul Korea"},{"name":"Institute of Allergy and Clinical Immunology Seoul National University Medical Research Center  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang\u2010Heon","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University College of Medicine  Seoul Korea"},{"name":"Institute of Allergy and Clinical Immunology Seoul National University Medical Research Center  Seoul Korea"},{"name":"Seoul National University Hospital Healthcare Gangnam Center  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,11]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"United Nations.World population aging: 1950\u20132050. 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