{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T06:07:36Z","timestamp":1790489256999,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,3,24]],"date-time":"2014-03-24T00:00:00Z","timestamp":1395619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2014,5]]},"abstract":"Abstract<\/jats:title>\n \n Background and objective<\/jats:title>\n \n Effective non\u2010invasive ventilation (\n NIV<\/jats:styled-content>\n ) therapy is dependent on optimal ventilator settings to maximize clinical benefit and patient tolerance. Intelligent volume\u2010assured pressure support (\n iVAPS<\/jats:styled-content>\n ) is a hybrid mode of servoventilation, providing constant automatic adjustment of pressure support (\n PS<\/jats:styled-content>\n ) to achieve a target ventilation determined by the patient's requirements. In a randomized crossover trial, we tested the hypothesis that\n iVAPS<\/jats:styled-content>\n , with automated selection of ventilator settings, was non\u2010inferior to standard\n PS<\/jats:styled-content>\n ventilation, with settings determined by an experienced health\u2010care professional, for controlling nocturnal hypoventilation in patients naive to\n NIV<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Eighteen patients referred to a ventilator clinic with chronic obstructive or restrictive lung disease and newly diagnosed nocturnal hypoventilation (10 male, median (interquartile range): age 54(41\u201361) years, mean daytime\n \n PaO\n 2<\/jats:sub>\n <\/jats:styled-content>\n 9.25(8.59\u201310.31) kPa, \u2010\n \n PaCO\n 2<\/jats:sub>\n <\/jats:styled-content>\n 6.38(5.93\u20136.65) kPa were randomized to\n iVAPS<\/jats:styled-content>\n and standard\n PS<\/jats:styled-content>\n . Polysomnography with transcutaneous\n \n CO\n 2<\/jats:sub>\n <\/jats:styled-content>\n monitoring was performed at baseline and 1 month after each treatment period. Nightly hours of therapy were recorded by the ventilator.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n iVAPS<\/jats:styled-content>\n delivered a lower median\n PS<\/jats:styled-content>\n compared with standard\n PS<\/jats:styled-content>\n (8.3(5.6\u201310.4) vs 10.0(9.0\u201311.4) cmH\n 2<\/jats:sub>\n O;\n P<\/jats:italic>\n \u2009=\u20090.001) for the same ventilatory outcome (mean overnight:\n \n SpO\n 2<\/jats:sub>\n <\/jats:styled-content>\n 96(95\u201398) vs 96(93\u201397)%;\n P<\/jats:italic>\n \u2009=\u20090.13 and\n \n PtcCO\n 2<\/jats:sub>\n <\/jats:styled-content>\n 6.5(5.8\u20136.8) vs 6.2(5.8\u20136.9);\n P<\/jats:italic>\n \u2009=\u20090.54). There was no difference in outcome between ventilator modes for spirometry, respiratory muscle strength, sleep quality, arousals or\n \n O\n 2<\/jats:sub>\n <\/jats:styled-content>\n desaturation index. Adherence was greater with\n iVAPS<\/jats:styled-content>\n (5:40(4:42\u20136:49) vs 4:20(2:27\u20136:17) hh:mm\/night;\n P<\/jats:italic>\n \u2009=\u20090.004).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n iVAPS<\/jats:styled-content>\n servoventilation with automation of ventilation settings is as effective as\n PS<\/jats:styled-content>\n ventilation initiated by a skilled health\u2010care professional in controlling nocturnal hypoventilation and produced better overnight adherence in patients naive to\n NIV<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/resp.12269","type":"journal-article","created":{"date-parts":[[2014,3,24]],"date-time":"2014-03-24T07:09:06Z","timestamp":1395644946000},"page":"596-603","source":"Crossref","is-referenced-by-count":74,"title":["Randomized trial of \u2018intelligent\u2019 autotitrating ventilation versus standard pressure support non\u2010invasive ventilation: Impact on adherence and physiological outcomes"],"prefix":"10.1111","volume":"19","author":[{"given":"Julia L.","family":"Kelly","sequence":"first","affiliation":[{"name":"Sleep and Ventilation Department NIHR Respiratory Disease Biomedical Research Unit at the Royal Brompton and Harefield NHS Foundation Trust and National Heart and Lung Institute Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Jaye","sequence":"additional","affiliation":[{"name":"Sleep and Ventilation Department NIHR Respiratory Disease Biomedical Research Unit at the Royal Brompton and Harefield NHS Foundation Trust and National Heart and Lung Institute Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel E.","family":"Pickersgill","sequence":"additional","affiliation":[{"name":"Sleep and Ventilation Department NIHR Respiratory Disease Biomedical Research Unit at the Royal Brompton and Harefield NHS Foundation Trust and National Heart and Lung Institute Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Chatwin","sequence":"additional","affiliation":[{"name":"Sleep and Ventilation Department NIHR Respiratory Disease Biomedical Research Unit at the Royal Brompton and Harefield NHS Foundation Trust and National Heart and Lung Institute Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary J.","family":"Morrell","sequence":"additional","affiliation":[{"name":"Sleep and Ventilation Department NIHR Respiratory Disease Biomedical Research Unit at the Royal Brompton and Harefield NHS Foundation Trust and National Heart and Lung Institute Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita K.","family":"Simonds","sequence":"additional","affiliation":[{"name":"Sleep and Ventilation Department NIHR Respiratory Disease Biomedical Research Unit at the Royal Brompton and Harefield NHS Foundation Trust and National Heart and Lung Institute Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.105.1.100"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.50.6.604"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00066704"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.123.1.67"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2012-201679"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.4.9904064"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-008-1276-4"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-007-0550-1"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-009-9167-1"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2008.03.013"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00065008"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/15412555.2010.528084"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.130.3.815"},{"key":"e_1_2_7_15_1","first-page":"145","article-title":"Staff training influence on non\u2010invasive ventilation outcome for acute hypercapnic respiratory failure","volume":"65","author":"Lopez\u2010Campos JL","year":"2006","journal-title":"Monaldi Arch Chest Dis."},{"key":"e_1_2_7_16_1","first-page":"267","article-title":"Noninvasive ventilation in acute respiratory failure","volume":"2","author":"Mehta S","year":"1996","journal-title":"Respir. 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