{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T12:14:35Z","timestamp":1770984875524,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,3,23]],"date-time":"2014-03-23T00:00:00Z","timestamp":1395532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Abnormal vocal cord movement may coexist with asthma and cause additional upper\/middle airway obstruction. The condition may be a form of muscular dystonia that could contribute to asthma resistant to optimised treatments. Botulinum toxin causes temporary paralysis of muscle and may be an effective local treatment that improves asthma control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In an observational study, we evaluated the benefits of unilateral vocal cord injection with botulinum toxin in 11 patients (total 24 injections). Subjects had asthma resistant to optimised treatment and abnormal vocal cord movement. Responses after botulinum toxin treatment were assessed using asthma control test (<jats:styled-content style=\"fixed-case\">ACT<\/jats:styled-content>) scores, vocal cord narrowing quantified by computerised tomography (<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>) of the larynx and spirometry. Side\u2010effects were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">ACT<\/jats:styled-content> scores improved overall (9.1\u2009\u00b1\u20092.4 before and 13.5\u2009\u00b1\u20094.5 after treatment; difference 4.4\u2009\u00b1\u20094.2; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). There was also an improvement in airway size on <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> larynx (time below lower limit of normal at baseline 39.4\u2009\u00b1\u200937.63% and improved to 17.6\u2009\u00b1\u200925.6% after injection; <jats:italic>P<\/jats:italic>\u2009=\u20090.032). Spirometry was not altered. One patient experienced an asthma exacerbation but overall side\u2010effects were moderate, chiefly dysphonia and dysphagia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although a placebo effect cannot be ruled out, local injection of botulinum toxin may be an effective treatment for intractable asthma associated with abnormal vocal cord movement. Further mechanistic studies and a double\u2010blind randomised controlled trial of botulinum toxin treatment are merited.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12271","type":"journal-article","created":{"date-parts":[[2014,3,24]],"date-time":"2014-03-24T03:38:56Z","timestamp":1395632336000},"page":"531-537","source":"Crossref","is-referenced-by-count":36,"title":["Abnormal vocal cord movement treated with botulinum toxin in patients with asthma resistant to optimised management"],"prefix":"10.1111","volume":"19","author":[{"given":"Malcolm","family":"Baxter","sequence":"first","affiliation":[{"name":"Ear, Nose and Throat Surgery Monash Medical Centre and Monash Institute of Medical Research (MIMR) Monash University  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nizam","family":"Uddin","sequence":"additional","affiliation":[{"name":"Monash Lung and Sleep Monash Medical Centre and Monash Institute of Medical Research (MIMR) Monash 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Medical Centre and Monash Institute of Medical Research (MIMR) Monash University  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Lau","sequence":"additional","affiliation":[{"name":"Diagnostic Imaging Monash Medical Centre and Monash Institute of Medical Research (MIMR) Monash University  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip G.","family":"Bardin","sequence":"additional","affiliation":[{"name":"Monash Lung and Sleep Monash Medical Centre and Monash Institute of Medical Research (MIMR) Monash University  Melbourne Victoria 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