{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:18:56Z","timestamp":1787015936158,"version":"build-2736575974"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,3,24]],"date-time":"2014-03-24T00:00:00Z","timestamp":1395619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2014,5]]},"abstract":"Abstract<\/jats:title>\n \n Background and objective<\/jats:title>\n \n Sleep\u2010disordered breathing (\n SDB<\/jats:styled-content>\n ) may develop in primary ciliary dyskinesia (\n PCD<\/jats:styled-content>\n ), leading to these diseases worsening one another.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Sixteen stable\n PCD<\/jats:styled-content>\n patients (4.9\u201317.2 years) and 42 controls underwent overnight respiratory polysomnography (\n rPSG<\/jats:styled-content>\n ) and Sleep Disturbances Scale for Children (\n SDSC<\/jats:styled-content>\n ). In\n PCD<\/jats:styled-content>\n we assessed nasal endoscopy, pulmonary function tests and chest high\u2010resolution computed tomography (\n HRCT<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Compared with controls,\n PCD<\/jats:styled-content>\n had higher obstructive apnoea (4.7 vs 0.2,\n P<\/jats:italic>\n \u2009<\u20090.001), central apnoea (0.8 vs 0.2,\n P<\/jats:italic>\n \u2009<\u20090.001), hypopnoea (1.8 vs 0.2,\n P<\/jats:italic>\n \u2009<\u20090.001), apnoea\u2013hypopnoea (7.8 vs 0.6,\n P<\/jats:italic>\n \u2009<\u20090.001), oxygen desaturation indexes (\n ODI<\/jats:styled-content>\n ; 0.7 vs 0.2,\n P<\/jats:italic>\n \u2009=\u20090.002), and mean oxygen desaturation (4% vs 1%,\n P<\/jats:italic>\n \u2009<\u20090.001), while mean and nadir oxygen saturation (97.1% vs 98.1,\n P<\/jats:italic>\n \u2009<\u20090.001) (93% vs 97.2%,\n P<\/jats:italic>\n \u2009<\u20090.001) were lower, respectively. In\n PCD<\/jats:styled-content>\n ,\n SDSC<\/jats:styled-content>\n was unrelated to\n rPSG<\/jats:styled-content>\n (\n P<\/jats:italic>\n \u2009>\u20090.05), with total score and subscores of disorders in initiating and maintaining sleep, and sleep\u2013wake transition lower than controls. PCD patients had chronic rhinosinusitis (100%) and adenoidal hypertrophy (50%). Total\n HRCT<\/jats:styled-content>\n score was 7 (range 0\u201314).\n ODI<\/jats:styled-content>\n correlated with functional residual capacity (\n r<\/jats:italic>\n \u2009=\u20090.8,\n P<\/jats:italic>\n \u2009=\u20090.02), total\n HRCT<\/jats:styled-content>\n (\n r<\/jats:italic>\n \u2009=\u20090.6,\n P<\/jats:italic>\n \u2009=\u20090.03) and peribronchial thickening scores (\n r<\/jats:italic>\n \u2009=\u20090.7,\n P<\/jats:italic>\n \u2009=\u20090.02). Oxygen saturation was associated with bronchiectasis severity score (\n r<\/jats:italic>\n \u2009=\u2009\u22120.6,\n P<\/jats:italic>\n \u2009=\u20090.02).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n PCD's parents may underestimate\n SDB<\/jats:styled-content>\n . As nocturnal desaturation is associated with lung function and structure abnormalities,\n SDB<\/jats:styled-content>\n may significantly contribute to pulmonary morbidity.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/resp.12273","type":"journal-article","created":{"date-parts":[[2014,3,24]],"date-time":"2014-03-24T07:17:21Z","timestamp":1395645441000},"page":"570-575","source":"Crossref","is-referenced-by-count":38,"title":["Sleep disordered breathing and airway disease in primary ciliary dyskinesia"],"prefix":"10.1111","volume":"19","author":[{"given":"Francesca","family":"Santamaria","sequence":"first","affiliation":[{"name":"Department of Translational Medical Sciences Reproductive and Odontostomatologic Sciences Unit of Ear, Nose and Throat and Molecular and Cellular Biology and Pathology Federico II University Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Esposito","sequence":"additional","affiliation":[{"name":"Sleep Clinic for Developmental Age Clinic of Child and Adolescent Neuropsychiatry Department of Mental and Physical Health, and Preventive Medicine Second University of Naples Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Montella","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences Reproductive and Odontostomatologic Sciences Unit of Ear, Nose and Throat and Molecular and Cellular Biology and Pathology Federico II University Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Cantone","sequence":"additional","affiliation":[{"name":"Department of Neurosciences Reproductive and Odontostomatologic Sciences Unit of Ear, Nose and Throat and Molecular and Cellular Biology and Pathology Federico II University Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmine","family":"Mollica","sequence":"additional","affiliation":[{"name":"Biostructure and Bioimaging Institute National Research Council Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"De Stefano","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences Reproductive and Odontostomatologic Sciences Unit of Ear, Nose and Throat and Molecular and Cellular Biology and Pathology Federico II University Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Mirra","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences Reproductive and Odontostomatologic Sciences Unit of Ear, Nose and Throat and Molecular and Cellular Biology and Pathology Federico II University Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Carotenuto","sequence":"additional","affiliation":[{"name":"Sleep Clinic for Developmental Age Clinic of Child and Adolescent Neuropsychiatry Department of Mental and Physical Health, and Preventive Medicine Second University of Naples Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.109.4.704"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.153.2.8564147"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-1998"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200604-577OC"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2006.096958"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201301-0059CI"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-010-1341-9"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.22710"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedhc.2008.04.001"},{"key":"e_1_2_6_11_1","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.2466\/pr0.1992.71.3f.1139","article-title":"Mothers of children with asthma: perceptions of parenting stress and the mother\u2010child relationship","volume":"71","author":"Carson DK","year":"1992","journal-title":"Psychol. 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