{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T10:18:36Z","timestamp":1791454716448,"version":"4.3.3"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Pulmonary vascular remodelling and inflammation have been implicated in pulmonary arterial hypertension (<jats:styled-content style=\"fixed-case\">PAH<\/jats:styled-content>). <jats:styled-content style=\"fixed-case\">YKL<\/jats:styled-content>\u201040, a marker of tissue remodelling and inflammation, has recently been recognized as a risk predictor of cardiovascular and inflammatory diseases. The study aimed to investigate a potential role of <jats:styled-content style=\"fixed-case\">YKL<\/jats:styled-content>\u201040 in predicting prognosis in idiopathic <jats:styled-content style=\"fixed-case\">PAH<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">IPAH<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Plasma <jats:styled-content style=\"fixed-case\">YKL<\/jats:styled-content>\u201040 levels were measured in 82 <jats:styled-content style=\"fixed-case\">IPAH<\/jats:styled-content> patients without current or previous <jats:styled-content style=\"fixed-case\">PAH<\/jats:styled-content>\u2010specific treatment during right heart catheterization and in 54 healthy volunteers. Concurrent data included clinical, haemodynamic and biochemical variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Plasma <jats:styled-content style=\"fixed-case\">YKL<\/jats:styled-content>\u201040 levels were increased in <jats:styled-content style=\"fixed-case\">IPAH<\/jats:styled-content> patients compared with control subjects (median, interquartile range: <jats:styled-content style=\"fixed-case\">IPAH<\/jats:styled-content>: 24.90, 17.68\u201339.78\u2009ng\/m<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>; controls: 16.58, 14.20\u201319.64\u2009ng\/m<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>; <jats:styled-content style=\"fixed-case\"><jats:italic>P<\/jats:italic><\/jats:styled-content>\u2009&lt;\u20090.001). <jats:styled-content style=\"fixed-case\">YKL<\/jats:styled-content>\u201040 levels correlated with cardiac index (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.244, <jats:styled-content style=\"fixed-case\"><jats:italic>P<\/jats:italic><\/jats:styled-content>\u2009=\u20090.027) and <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>\u2010terminal pro\u2010brain natriuretic peptide (<jats:styled-content style=\"fixed-case\">NT<\/jats:styled-content>\u2010proBNP, <jats:italic>r<\/jats:italic>\u2009=\u20090.263, <jats:styled-content style=\"fixed-case\"><jats:italic>P<\/jats:italic><\/jats:styled-content>\u2009=\u20090.017). After a median follow\u2010up of 578 days, <jats:styled-content style=\"fixed-case\">YKL<\/jats:styled-content>\u201040 outperformed <jats:styled-content style=\"fixed-case\">NT<\/jats:styled-content>\u2010pro<jats:styled-content style=\"fixed-case\">BNP<\/jats:styled-content>, uric acid, and 6\u2010min walk distance in receiver operating characteristic (<jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content>) analyses in predicting both clinical worsening (area under the curve (<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>) 0.681) and death (<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content> 0.717). Compared with patients with <jats:styled-content style=\"fixed-case\">YKL<\/jats:styled-content>\u201040 below the <jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content>\u2010derived cut\u2010off point (24.5\u2009ng\/m<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>), the high <jats:styled-content style=\"fixed-case\">YKL<\/jats:styled-content>\u201040 group showed higher pulmonary vascular resistance and serum uric acid levels, and showed more clinical worsening events and deaths in <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>aplan\u2013<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>eier analyses. Plasma <jats:styled-content style=\"fixed-case\">YKL<\/jats:styled-content>\u201040 was independently associated with clinical worsening in univariate and multivariate <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ox analyses (all <jats:styled-content style=\"fixed-case\"><jats:italic>P<\/jats:italic><\/jats:styled-content>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Plasma <jats:styled-content style=\"fixed-case\">YKL<\/jats:styled-content>\u201040 might serve as a promising indicator of disease severity and prognosis in patients with <jats:styled-content style=\"fixed-case\">IPAH<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12283","type":"journal-article","created":{"date-parts":[[2014,4,2]],"date-time":"2014-04-02T01:03:33Z","timestamp":1396400613000},"page":"608-615","source":"Crossref","is-referenced-by-count":18,"title":["Elevated plasma <scp>YKL<\/scp>\u201040 as a prognostic indicator in patients with idiopathic pulmonary arterial hypertension"],"prefix":"10.1111","volume":"19","author":[{"given":"Guo","family":"Chen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Gu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin\u2010Hai","family":"Ni","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi\u2010Hui","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jue","family":"Ye","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical 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