{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T03:49:04Z","timestamp":1783655344750,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Reliable markers of disease progression or stability to assist in management decisions are lacking in patients with non\u2010cystic fibrosis bronchiectasis and <jats:italic>Mycobacterium avium<\/jats:italic> complex (<jats:styled-content style=\"fixed-case\">MAC<\/jats:styled-content>) infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from 52 adults with non\u2010cystic fibrosis bronchiectasis and coexisting <jats:styled-content style=\"fixed-case\">MAC<\/jats:styled-content> infection managed at our institution over a 5\u2010year period were retrospectively analysed. High\u2010resolution computed tomography (HRCT) scans were scored using a scoring system that focused on findings associated with <jats:styled-content style=\"fixed-case\">MAC<\/jats:styled-content> infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Chronic pulmonary aspergillosis was independently associated with mortality (hazard ratio (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>)\u2009=\u20098.916, 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>)\u2009=\u20091.324\u201360.027), as were nodules with cavitation (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2009=\u20095.911, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u2009=\u20091.095\u201325.911) and emphysema (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2009=\u20091.027, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u2009=\u20091.002\u20131.053) on <jats:styled-content style=\"fixed-case\">HRCT<\/jats:styled-content>. Anti\u2010<jats:styled-content style=\"fixed-case\">MAC<\/jats:styled-content> chemotherapy was more likely to lead to <jats:styled-content style=\"fixed-case\">MAC<\/jats:styled-content> culture conversion (67% vs 27%, <jats:styled-content style=\"fixed-case\"><jats:italic>P<\/jats:italic><\/jats:styled-content>\u2009=\u20090.005) but did not improve survival as compared with patients managed with observation. Longitudinally, patients who had improvements in <jats:styled-content style=\"fixed-case\">HRCT<\/jats:styled-content> scores were younger (60.2\u2009\u00b1\u20099.19 years vs 69.83\u2009\u00b1\u200912.43 years, <jats:styled-content style=\"fixed-case\"><jats:italic>P<\/jats:italic><\/jats:styled-content>\u2009=\u20090.043), while the presence of cavitation within nodules predicted a deterioration in <jats:styled-content style=\"fixed-case\">HRCT<\/jats:styled-content> scores (0.5 (0\u20133) vs 0 (0\u20131), <jats:styled-content style=\"fixed-case\"><jats:italic>P<\/jats:italic><\/jats:styled-content>\u2009=\u20090.033). No significant longitudinal differences were found in lung function in the cohort as a whole or within different groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Chronic pulmonary aspergillosis in patients with bronchiectasis and coexisting <jats:styled-content style=\"fixed-case\">MAC<\/jats:styled-content> infection is a strong predictor of mortality. Cavitation within nodules and emphysema on <jats:styled-content style=\"fixed-case\">HRCT<\/jats:styled-content> at presentation were independently associated with mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12287","type":"journal-article","created":{"date-parts":[[2014,4,2]],"date-time":"2014-04-02T01:03:59Z","timestamp":1396400639000},"page":"714-722","source":"Crossref","is-referenced-by-count":69,"title":["<i>Mycobacterium avium<\/i> complex infection in non\u2010cystic fibrosis bronchiectasis"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2533-6160","authenticated-orcid":false,"given":"Zaid","family":"Zoumot","sequence":"first","affiliation":[{"name":"National Institute for Health Research Respiratory Biomedical Research Unit Royal Brompton and Harefield Hospital Foundation Trust and Imperial College"},{"name":"Host Defence Unit"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afroditi K.","family":"Boutou","sequence":"additional","affiliation":[{"name":"National Institute for Health Research Respiratory Biomedical Research Unit Royal Brompton and Harefield Hospital Foundation Trust and Imperial College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon S.","family":"Gill","sequence":"additional","affiliation":[{"name":"Department of Radiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mafalda","family":"van Zeller","sequence":"additional","affiliation":[{"name":"Host Defence Unit"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Hansell","sequence":"additional","affiliation":[{"name":"National Institute for Health Research Respiratory Biomedical Research Unit Royal Brompton and Harefield Hospital Foundation Trust and Imperial College"},{"name":"Department of Radiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athol U.","family":"Wells","sequence":"additional","affiliation":[{"name":"National Institute for Health Research Respiratory Biomedical Research Unit Royal Brompton and Harefield Hospital Foundation Trust and Imperial College"},{"name":"Interstitial Lung Disease Unit Royal Brompton and Harefield NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Wilson","sequence":"additional","affiliation":[{"name":"National Institute for Health Research Respiratory Biomedical Research Unit Royal Brompton and Harefield Hospital Foundation Trust and Imperial College"},{"name":"Host Defence Unit"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Loebinger","sequence":"additional","affiliation":[{"name":"National Institute for Health Research Respiratory Biomedical Research Unit Royal Brompton and Harefield Hospital Foundation Trust and Imperial College"},{"name":"Host Defence 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