{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T05:06:28Z","timestamp":1785474388030,"version":"3.56.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T00:00:00Z","timestamp":1397952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and objective<\/jats:title>\n                    <jats:p>\n                      The gold standard for the histological diagnosis of interstitial lung diseases (\n                      <jats:styled-content style=\"fixed-case\">ILD<\/jats:styled-content>\n                      ) is an open lung biopsy (\n                      <jats:styled-content style=\"fixed-case\">OLB<\/jats:styled-content>\n                      ). Tissue samples obtained by forceps transbronchial lung biopsies (\n                      <jats:styled-content style=\"fixed-case\">TBB<\/jats:styled-content>\n                      ) are usually too small. We aim to evaluate the efficacy and safety of cryo\u2010\n                      <jats:styled-content style=\"fixed-case\">TBB<\/jats:styled-content>\n                      for the diagnosis of\n                      <jats:styled-content style=\"fixed-case\">ILD<\/jats:styled-content>\n                      and to explore its role as substitute for\n                      <jats:styled-content style=\"fixed-case\">OLB<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Seventy\u2010five patients (mean age 56.2 years) with clinical and radiological features suggestive of\n                      <jats:styled-content style=\"fixed-case\">ILD<\/jats:styled-content>\n                      underwent cryo\u2010\n                      <jats:styled-content style=\"fixed-case\">TBB<\/jats:styled-content>\n                      under moderate sedation. The diagnostic contribution on the work\u2010up of suspected\n                      <jats:styled-content style=\"fixed-case\">ILD<\/jats:styled-content>\n                      was assessed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No major complications occurred during cryo\u2010\n                      <jats:styled-content style=\"fixed-case\">TBB<\/jats:styled-content>\n                      procedures. The mean cross\u2010sectional area of the biopsy specimen obtained was 9\u2009mm\n                      <jats:sup>2<\/jats:sup>\n                      with an average of 70% alveolated tissue. The most common pathological diagnoses were idiopathic nonspecific interstitial pneumonitis (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200922), cryptogenic organizing pneumonia (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200911) and usual interstitial pneumonitis (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20097). There were three patients of pulmonary Langerhans cell histiocytosis and one patient of pulmonary lymphangioleiomyomatosis. A definite and probable clinicopathological consensus diagnosis was possible in 70% and 28% of patients, respectively. In only 2% of patients' diagnosis could not be established.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Cryo\u2010\n                      <jats:styled-content style=\"fixed-case\">TBB<\/jats:styled-content>\n                      is a safe and effective minimally invasive modality for the diagnosis of\n                      <jats:styled-content style=\"fixed-case\">ILD<\/jats:styled-content>\n                      . No\n                      <jats:styled-content style=\"fixed-case\">OLB<\/jats:styled-content>\n                      is needed in the majority of patients.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/resp.12296","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T22:32:46Z","timestamp":1398033166000},"page":"683-688","source":"Crossref","is-referenced-by-count":128,"title":["Histological diagnosis of interstitial lung diseases by cryo\u2010transbronchial biopsy"],"prefix":"10.1111","volume":"19","author":[{"given":"Oren","family":"Fruchter","sequence":"first","affiliation":[{"name":"Institute of Pulmonary Rabin Medical Center Petah Tiqwa Israel"},{"name":"The Sackler School of Medicine Tel\u2010Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludmila","family":"Fridel","sequence":"additional","affiliation":[{"name":"Department of Pathology Rabin Medical Center Petah Tiqwa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bayya Abed","family":"El Raouf","sequence":"additional","affiliation":[{"name":"Institute of Pulmonary Rabin Medical Center Petah Tiqwa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nader","family":"Abdel\u2010Rahman","sequence":"additional","affiliation":[{"name":"Institute of Pulmonary Rabin Medical Center Petah Tiqwa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dror","family":"Rosengarten","sequence":"additional","affiliation":[{"name":"Institute of Pulmonary Rabin Medical Center Petah Tiqwa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mordechai R.","family":"Kramer","sequence":"additional","affiliation":[{"name":"Institute of Pulmonary Rabin Medical Center Petah Tiqwa Israel"},{"name":"The Sackler School of Medicine Tel\u2010Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200503-483OE"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201308-1483ST"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.4065\/82.8.976"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2012-0225-RA"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.5_suppl_1.520S"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00001213"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rppneu.2011.09.004"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rppneu.2011.05.003"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"107\u2009s","DOI":"10.1183\/09031936.01.18s320107","article-title":"Classifying interstitial lung diseases in a fractal lung: a morphologist's view \u2018anno Domini 2000\u2019","volume":"32","author":"Verbeken EK","year":"2001","journal-title":"Eur. 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