{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:22:46Z","timestamp":1740126166260,"version":"3.37.3"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,5,6]],"date-time":"2014-05-06T00:00:00Z","timestamp":1399334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council Taiwan","doi-asserted-by":"publisher","award":["NSC 99-2314-B-006-040"],"award-info":[{"award-number":["NSC 99-2314-B-006-040"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001868","name":"National Science Council Taiwan","doi-asserted-by":"publisher","award":["NSC 101-2314-B-006-073"],"award-info":[{"award-number":["NSC 101-2314-B-006-073"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2014,7]]},"abstract":"Abstract<\/jats:title>Background and objective<\/jats:title>Chronic obstructive pulmonary disease (COPD<\/jats:styled-content>) is a pulmonary disease with systemic involvement. Several multidimensional indices have been developed to predict long\u2010term outcomes. However, these indices have not been compared and validated in T<\/jats:styled-content>aiwanese patients with COPD<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>A prospective, observational, hospital\u2010based study was designed, and a total of 621 patients were recruited from M<\/jats:styled-content>ay 2006 to D<\/jats:styled-content>ecember 2011. Patients followed at least 1 year were enrolled and 594 patients eligible for inclusion. Three prognostic indices\u2014the ADO<\/jats:styled-content> (age, dyspnoea and airflow obstruction), BODEx<\/jats:styled-content> (body mass index, airflow obstruction, dyspnoea and exacerbations), and CPI<\/jats:styled-content> (the COPD P<\/jats:styled-content>rognostic I<\/jats:styled-content>ndex)\u2014were validated and the predictive power of each was analysed.<\/jats:p><\/jats:sec>Results<\/jats:title>The median follow\u2010up of the 594 patients was 33 months (range 1\u201372 months), and the mortality rate was 19.2% (114 deaths). All indices were significantly predictive for all\u2010cause mortality in our validation cohort. Furthermore, the C<\/jats:styled-content> statistics of the three indices, indicating their predictive accuracy, were all >0.7 (area under the curve of the CPI<\/jats:styled-content> 0.718, P<\/jats:italic><\/jats:styled-content>\u2009<\u20090.001, ADO<\/jats:styled-content> 0.702, P<\/jats:italic><\/jats:styled-content>\u2009<\u20090.001, BODEx<\/jats:styled-content> 0.702, P<\/jats:italic><\/jats:styled-content>\u2009<\u20090.001).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>ADO<\/jats:styled-content>, BODEx<\/jats:styled-content> and CPI<\/jats:styled-content> scores are useful predictors of all\u2010cause mortality with significantly discriminative properties in T<\/jats:styled-content>aiwanese patients with COPD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12313","type":"journal-article","created":{"date-parts":[[2014,5,6]],"date-time":"2014-05-06T09:52:20Z","timestamp":1399369940000},"page":"694-699","source":"Crossref","is-referenced-by-count":7,"title":["Discriminative and predictive properties of multidimensional prognostic indices of chronic obstructive pulmonary disease: A validation study in T<\/scp>aiwanese patients"],"prefix":"10.1111","volume":"19","author":[{"given":"Chih\u2010Ying","family":"Ou","sequence":"first","affiliation":[{"name":"Division of Chest Medicine Department of Internal Medicine National Cheng Kung University Hospital Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiung\u2010Zuei","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Chest Medicine Department of Internal Medicine National Cheng Kung University Hospital Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun\u2010Hsiang","family":"Yu","sequence":"additional","affiliation":[{"name":"Division of Chest Medicine National Cheng Kung University Hospital Dou\u2010Liou Branch College of Medicine National Cheng Kung University Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih\u2010Hui","family":"Shiu","sequence":"additional","affiliation":[{"name":"Division of Chest Medicine Department of Internal Medicine National Cheng Kung University Hospital Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzuen\u2010Ren","family":"Hsiue","sequence":"additional","affiliation":[{"name":"Division of Chest Medicine Department of Internal Medicine National Cheng Kung University Hospital Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,5,6]]},"reference":[{"unstructured":"World Health Organization.The World Health Report 2002.2002. 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