{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T19:34:59Z","timestamp":1791833699019,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,5,9]],"date-time":"2014-05-09T00:00:00Z","timestamp":1399593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Chinese Key Projects in the National Science & Technology Pillar Program during the Twelfth Five-year Plan Period","award":["2012BA105B02"],"award-info":[{"award-number":["2012BA105B02"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2014,7]]},"abstract":"Abstract<\/jats:title>Pulmonary hypertension has been recognized as being associated with obstructive sleep apnoea (OSA<\/jats:styled-content>). Continuous positive airway pressure (CPAP<\/jats:styled-content>) might reduce pulmonary artery pressure in OSA<\/jats:styled-content> patients; however, evidence from clinical studies is limited and inconsistent. This meta\u2010analysis aims to assess whether CPAP<\/jats:styled-content> is associated with a decrease in pulmonary artery pressure in patients with OSA<\/jats:styled-content>. This systematic review was performed in accordance with the M<\/jats:styled-content>eta\u2010analysis of O<\/jats:styled-content>bservational S<\/jats:styled-content>tudies in E<\/jats:styled-content>pidemiology guidelines. Published studies were identified through a search in MEDLINE<\/jats:styled-content>, EMBASE<\/jats:styled-content> and the C<\/jats:styled-content>ochrane library through to M<\/jats:styled-content>ay 2013. Two reviewers sorted papers and extracted data. A random\u2010effects model was used to combine results across studies comparing pulmonary artery pressure in OSA<\/jats:styled-content> patients before and after CPAP<\/jats:styled-content> treatment. Six articles with 181 patients were included in this meta\u2010analysis, including five before\u2010after studies and one matched\u2010control study. The meta\u2010analysis showed that CPAP<\/jats:styled-content> was associated with a statistically significant reduction in pulmonary artery pressure in OSA<\/jats:styled-content> patients (standardized mean difference \u22121.34, 95% confidence interval: \u22122.33 to \u22120.34, P<\/jats:italic>\u2009=\u20090.009). Although this meta\u2010analysis has some limitations, it indicates that CPAP<\/jats:styled-content> is associated with a decrease in pulmonary artery pressure in patients with OSA<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/resp.12314","type":"journal-article","created":{"date-parts":[[2014,5,9]],"date-time":"2014-05-09T10:24:01Z","timestamp":1399631041000},"page":"670-674","source":"Crossref","is-referenced-by-count":30,"title":["Continuous positive airway pressure is associated with a decrease in pulmonary artery pressure in patients with obstructive sleep apnoea: A meta\u2010analysis"],"prefix":"10.1111","volume":"19","author":[{"given":"Xuefeng","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine Peking Union Medical College Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinmei","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Peking Union Medical College Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Peking Union Medical College Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199304293281704"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000132476.87231.6F"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.01.004"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.06.048"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.07.015"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.126.1_suppl.72S"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.15.2008"},{"key":"e_1_2_7_9_1","volume-title":"Statistical Methods for Meta\u2010Analysis","author":"Hedges LV","year":"1985"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.epirev.a036084"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(86)90046-2"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.97.10112578"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000050574"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.165.2.2010092"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi807"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00063-006-1003-2"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-0615"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200505-702OC"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200509-1442OC"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005113421901"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)71141-7"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.96.4.729"},{"key":"e_1_2_7_24_1","first-page":"795","article-title":"Obstructive sleep apnea syndrome and the pulmonary circulation","volume":"6","author":"Weitzenblum E","year":"2005","journal-title":"Ital. 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