{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T08:46:30Z","timestamp":1789980390544,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,6,9]],"date-time":"2014-06-09T00:00:00Z","timestamp":1402272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"programme hospitalier de recherche clinique","award":["API 26-07"],"award-info":[{"award-number":["API 26-07"]}]},{"name":"The AGIR a dom Scientific Council, Grenoble France"},{"name":"The ALLP Scientific Council, Lyon France"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2014,8]]},"abstract":"Abstract<\/jats:title>Background and objective<\/jats:title>Long\u2010term non\u2010invasive ventilation (NIV<\/jats:styled-content>) has become a widespread modality of treatment in chronic obstructive pulmonary disease (COPD<\/jats:styled-content>) patients with chronic respiratory failure. However, benefits in terms of patient\u2010related outcomes are still under debate. Both NIV<\/jats:styled-content> adherence and heterogeneous responses in different COPD<\/jats:styled-content> phenotypes may contribute to the difficulty of demonstrating NIV<\/jats:styled-content> benefits. Our aim was to assess the impact of NIV<\/jats:styled-content> adherence on the rate of hospitalization for acute exacerbation and death.<\/jats:p><\/jats:sec>Methods<\/jats:title>This is a prospective multi\u2010centre cohort study of COPD<\/jats:styled-content> patients treated by long\u2010term NIV<\/jats:styled-content>. Comorbidities, anthropometrics, respiratory parameters were collected at inclusion in the study. Follow\u2010up data included vital status, NIV<\/jats:styled-content> adherence and hospitalizations. The influence of NIV<\/jats:styled-content> adherence on prognosis was tested using an adjusted C<\/jats:styled-content>ox model. Sensitivity analyses for obese and non\u2010obese COPD<\/jats:styled-content> subtypes were also conducted.<\/jats:p><\/jats:sec>Results<\/jats:title>Two hundred thirteen patients (48% obese) were included with 45.5% died during 47.7 [interquartile range\u2009=\u200927.8; 73] months' follow\u2010up. Survival was better in obese COPD<\/jats:styled-content> than non\u2010obese COPD<\/jats:styled-content>. The use of NIV<\/jats:styled-content>\u2009>\u20099\u2009h\/day was associated with an increased risk of death or hospitalization for acute exacerbation [HR<\/jats:styled-content>\u2009=\u20091.6; 95CI<\/jats:styled-content>: 1.1\u20132.4]. In obese COPD<\/jats:styled-content>, this risk described a U<\/jats:styled-content>\u2010shaped curve from >1 to >9\u2009h\/day NIV<\/jats:styled-content> usage with an improvement in prognosis when NIV<\/jats:styled-content> adherence was\u2009>\u20095\u2009h\/day [HR<\/jats:styled-content>\u2009=\u20090.5; 95CI<\/jats:styled-content>: 0.2\u20130.9].<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Adherence to NIV<\/jats:styled-content> was associated with better prognosis only in obese COPD<\/jats:styled-content>. NIV<\/jats:styled-content> use\u2009>\u20099\u2009h\/day predicted poor outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12327","type":"journal-article","created":{"date-parts":[[2014,6,10]],"date-time":"2014-06-10T01:13:01Z","timestamp":1402362781000},"page":"857-865","source":"Crossref","is-referenced-by-count":72,"title":["Long\u2010term adherence with non\u2010invasive ventilation improves prognosis in obese COPD<\/scp> patients"],"prefix":"10.1111","volume":"19","author":[{"given":"Jean\u2010Christian","family":"Borel","sequence":"first","affiliation":[{"name":"INSERM Unit 1042 Grenoble Alpes University Grenoble France"},{"name":"Physiology and Sleep Unit Michallon University Hospital Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Louis","family":"Pepin","sequence":"additional","affiliation":[{"name":"INSERM Unit 1042 Grenoble Alpes University Grenoble France"},{"name":"Physiology and Sleep Unit Michallon University Hospital Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Pison","sequence":"additional","affiliation":[{"name":"INSERM Unit 1055 Grenoble Alpes University Grenoble France"},{"name":"Pneumology Unit Michallon University Hospital Grenoble France"},{"name":"European Institute for Systems Biology and Medicine EISBM Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lien","family":"Vesin","sequence":"additional","affiliation":[{"name":"INSERM Unit 823 Grenoble Alpes University La Tronche France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus","family":"Gonzalez\u2010Bermejo","sequence":"additional","affiliation":[{"name":"Intensive Care and Pneumology Unit Piti\u00e9\u2010Salp\u00eatri\u00e8re University Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Court\u2010Fortune","sequence":"additional","affiliation":[{"name":"Pneumology Unit Saint\u2010Etienne University Hospital Saint Etienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Fran\u00e7ois","family":"Timsit","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, A Michallon University Hospital Grenoble France"},{"name":"INSERM Unit 823 Grenoble Alpes University La Tronche 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