{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T21:36:27Z","timestamp":1778708187878,"version":"3.51.4"},"reference-count":99,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,6,19]],"date-time":"2014-06-19T00:00:00Z","timestamp":1403136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The approach to management of malignant pleural effusions (<jats:styled-content style=\"fixed-case\">MPE<\/jats:styled-content>) has changed over the past few decades. The key goals of <jats:styled-content style=\"fixed-case\">MPE<\/jats:styled-content> management are to relieve patient symptoms using the least invasive means and in the most cost\u2010effective manner. There is now a realization that patient\u2010reported outcome measures should be the primary goal of <jats:styled-content style=\"fixed-case\">MPE<\/jats:styled-content> treatment, and this now is the focus in most clinical trials. Efforts to minimize patient morbidity are complemented by development of less invasive treatments that have mostly replaced the more aggressive surgical approaches of the past. Therapeutic thoracentesis is simple, effective and generally safe, although its benefits may only be temporary. Pleurodesis is the conventional and for a long time the only definitive therapy available. However, the efficacy and safety of talc pleurodesis has been challenged. Indwelling pleural catheter (<jats:styled-content style=\"fixed-case\">IPC<\/jats:styled-content>) drainage is increasingly accepted worldwide and represents a new concept to improve symptoms without necessarily generating pleural symphysis. Recent studies support the effectiveness of <jats:styled-content style=\"fixed-case\">IPC<\/jats:styled-content> treatment and provide reassurance regarding its safety. An unprecedented number of clinical trials are now underway to improve various aspects of <jats:styled-content style=\"fixed-case\">MPE<\/jats:styled-content> care. However, choosing an optimal intervention for <jats:styled-content style=\"fixed-case\">MPE<\/jats:styled-content> in an individual patient remains a challenge due to our limited understanding of the underlying pathophysiology of breathlessness in <jats:styled-content style=\"fixed-case\">MPE<\/jats:styled-content> and a lack of predictors of survival and pleurodesis outcome. This review provides an overview of common pleural interventional procedures used for <jats:styled-content style=\"fixed-case\">MPE<\/jats:styled-content> management, controversies and limitations of current practice, and areas of research most needed to improve practice in future.<\/jats:p>","DOI":"10.1111\/resp.12328","type":"journal-article","created":{"date-parts":[[2014,6,20]],"date-time":"2014-06-20T02:15:36Z","timestamp":1403230536000},"page":"809-822","source":"Crossref","is-referenced-by-count":56,"title":["Interventional therapies for malignant pleural effusions: The present and the future"],"prefix":"10.1111","volume":"19","author":[{"given":"Rajesh","family":"Thomas","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Sir Charles Gairdner Hospital  Perth Western Australia Australia"},{"name":"School of Medicine and Pharmacology University of Western Australia  Perth Western Australia Australia"},{"name":"Pleural Disease Unit Lung Institute of Western Australia  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roslyn","family":"Francis","sequence":"additional","affiliation":[{"name":"School of Medicine and Pharmacology University of Western Australia  Perth Western Australia Australia"},{"name":"Department of Nuclear Medicine Sir Charles Gairdner Hospital  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen E.","family":"Davies","sequence":"additional","affiliation":[{"name":"University Hospital of Wales  Cardiff Wales UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.C. Gary","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Sir Charles Gairdner Hospital  Perth Western Australia Australia"},{"name":"School of Medicine and Pharmacology University of Western Australia  Perth Western Australia Australia"},{"name":"Pleural Disease Unit Lung Institute of Western Australia  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,6,19]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Pleural Diseases","author":"Light RW","year":"2001"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdl498"},{"key":"e_1_2_7_4_1","first-page":"353","volume-title":"Encyclopedia of Respiratory Diseases","author":"Lee YC","year":"2006"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.107.6.1598"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.127.3.909"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.137026"},{"key":"e_1_2_7_8_1","unstructured":"National Patient Safety Agency.Rapid Response Report: Risks of Chest Drain Insertion. NPSA London 2008. [Accessed 3 June 2014.] Available from URL:http:\/\/www.12npsa.nhs.uk\/nrls\/alerts\u2010and\u2010directives\/rapidrr\/risks\u2010of\u2010chest\u2010drain\u2010insertion\/."},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2657"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0b013e3283615b67"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.5535"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.136994"},{"key":"e_1_2_7_13_1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0096-5588(20)32384-9","article-title":"Pleural poudrage: a new technique for deliberate production of pleural adhesions as a preliminary to lobectomy","volume":"4","author":"Bethune N","year":"1935","journal-title":"J. Thorac. Surg."},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3182114aa0"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.117.1.87"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.11.136"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-1679"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(83)91072-0"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.107.6.1610"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1985.59.5.1458"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1148\/84.6.1080"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2012-203043"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00069812"},{"key":"e_1_2_7_24_1","first-page":"23","article-title":"Clinical response of gefitinib on malignant pleural effusions in patients with non\u2010small cell lung cancer","volume":"4","author":"Chen CH","year":"2008","journal-title":"J. Cancer Mol."},{"key":"e_1_2_7_25_1","first-page":"880","article-title":"EGFR mutations predict a favorable outcome for malignant pleural effusion of lung adenocarcinoma with Tarceva therapy","volume":"27","author":"Guo H","year":"2012","journal-title":"Oncol. Rep."},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2011.06.004"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.123.2.418"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2007.06.038"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-004-2536-x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00037906"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2004.03.010"},{"key":"e_1_2_7_32_1","doi-asserted-by":"crossref","DOI":"10.1016\/B978-1-4377-1560-6.00058-5","volume-title":"Lung, Chest Wall, Pleura, and Mediastinum","author":"Putnam JB","year":"2012"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(97)00105-X"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.99.2.270"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.107.5.1454"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.107.3.845"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2005.12.025"},{"key":"e_1_2_7_38_1","first-page":"131","article-title":"Treatment of malignant pleural effusion with drainage, with and without instillation of talc","volume":"65","author":"Sorensen PG","year":"1984","journal-title":"Eur. J. Respir. Dis."},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-2448"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(96)00808-9"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(86)90009-X"},{"key":"e_1_2_7_42_1","first-page":"PI54","article-title":"Talc powder vs doxycycline in the control of malignant pleural effusion: a prospective, randomized trial","volume":"9","author":"Kuzdzal J","year":"2003","journal-title":"Med. Sci. Monit."},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800761214"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.4.2002030"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1080\/17843286.1997.11718587"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.112.2.430"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1843.2000.00235.x"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-004-7269-8"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19830815)52:4<737::AID-CNCR2820520428>3.0.CO;2-8"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.2.684"},{"key":"e_1_2_7_51_1","first-page":"282","article-title":"Local iodine pleurodesis versus thoracoscopic talc insufflation in recurrent malignant pleural effusion: a prospective randomized control trial","volume":"40","author":"Mohsen TA","year":"2011","journal-title":"Eur. J. Cardiothorac Surg."},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2012.0102"},{"key":"e_1_2_7_53_1","volume-title":"Textbook of Pleural Diseases","author":"Davies HE"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.124.6.2229"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.04.00137403"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2003.09.014"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2011.01999.x"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.126.5.1529"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70205-5"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002916.pub2"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2007.092940"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.119.6.1901"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.122.3.1018"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.115.1.190"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.117.1.73"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1159\/000029240"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.97.10071648"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.49.1.23"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2006.06.004"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.121.1.216"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcp.0000166587.24127.91"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-2366"},{"issue":"2","key":"e_1_2_7_73_1","doi-asserted-by":"crossref","first-page":"ii29","DOI":"10.1136\/thx.58.suppl_2.ii29","article-title":"BTS guidelines for the management of malignant pleural effusions","volume":"58","author":"Antunes G","year":"2003","journal-title":"Thorax"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-010-1472-0"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1510\/icvts.2009.211516"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1177\/021849230801600208"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.119.6.1641"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19991115)86:10<1992::AID-CNCR16>3.0.CO;2-M"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.129.2.362"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2013.03.063"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2012.01.103"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/842768"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2008.06.009"},{"key":"e_1_2_7_84_1","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1177\/000313480306900304","article-title":"Use of an indwelling pleural catheter compared with thorascopic talc pleurodesis in the management of malignant pleural effusions","volume":"69","author":"Ohm C","year":"2003","journal-title":"Am. Surg."},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00164706"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-1868"},{"key":"e_1_2_7_87_1","doi-asserted-by":"publisher","DOI":"10.3109\/01902148.2012.731715"},{"key":"e_1_2_7_88_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-3103"},{"key":"e_1_2_7_89_1","doi-asserted-by":"publisher","DOI":"10.1097\/LBR.0000000000000001"},{"key":"e_1_2_7_90_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.13\u20103057"},{"key":"e_1_2_7_91_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198810000-00006"},{"key":"e_1_2_7_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(00)00422-X"},{"key":"e_1_2_7_93_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-126-10-199705150-00003"},{"key":"e_1_2_7_94_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200804-616ED"},{"key":"e_1_2_7_95_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201203-0465PP"},{"key":"e_1_2_7_96_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200710-1513OC"},{"key":"e_1_2_7_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605814"},{"key":"e_1_2_7_98_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201103-0554CR"},{"key":"e_1_2_7_99_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-0403"},{"key":"e_1_2_7_100_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2009.309"}],"container-title":["Respirology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fresp.12328","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/resp.12328","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T21:23:36Z","timestamp":1696022616000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/resp.12328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,19]]},"references-count":99,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1111\/resp.12328"],"URL":"https:\/\/doi.org\/10.1111\/resp.12328","archive":["Portico"],"relation":{},"ISSN":["1323-7799","1440-1843"],"issn-type":[{"value":"1323-7799","type":"print"},{"value":"1440-1843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,19]]}}}