{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:59:52Z","timestamp":1791248392894,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,6,17]],"date-time":"2014-06-17T00:00:00Z","timestamp":1402963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2014,8]]},"abstract":"Abstract<\/jats:title>Intrathoracic lymph node metastases in patients with extrathoracic malignancies are a common clinical manifestation. Several studies evaluating intrathoracic lymph node metastases in patients with extrathoracic malignancy by using the endobronchial ultrasound\u2010guided transbronchial needle aspiration (EBUS\u2010TBNA<\/jats:styled-content>) have been reported. The objective of this meta\u2010analysis is to investigate the diagnostic value of EBUS\u2010TBNA<\/jats:styled-content> for diagnosing intrathoracic lymph node metastases in patients with extrathoracic malignancies. We systematically searched C<\/jats:styled-content>ochrane L<\/jats:styled-content>ibrary, M<\/jats:styled-content>edline and E<\/jats:styled-content>mbase for relevant studies published prior to M<\/jats:styled-content>ay 2013. Studies specifically designed to evaluate the diagnostic accuracy of EBUS\u2010TBNA<\/jats:styled-content> for intrathoracic lymph node metastases in patients with an extrathoracic malignancy were selected. Diagnostic accuracy meta\u2010analysis was conducted by pooling estimates of sensitivity, specificity, negative likelihood ratio (NLR<\/jats:styled-content>), positive likelihood ratio (PLR<\/jats:styled-content>) and diagnostic odds ratios (DOR<\/jats:styled-content>) derived from a summary receiver operating characteristic (SROC<\/jats:styled-content>) analysis of the original studies. Six studies were included, which provided a dataset of 533 patients. EBUS\u2010TBNA<\/jats:styled-content> pooled estimates had 0.85 sensitivity (95% confidence interval (CI<\/jats:styled-content>): 0.80\u20130.89), 0.99 specificity (95% CI<\/jats:styled-content>: 0.95\u20131.00), PLR<\/jats:styled-content> 28.63 (95% CI<\/jats:styled-content>: 11.51\u201371.22) and NLR<\/jats:styled-content> 0.16 (95% CI<\/jats:styled-content>: 0.12\u20130.21). The overall DOR<\/jats:styled-content> was 179.77 (95% CI<\/jats:styled-content>: 66.29\u2013487.50). The area under the SROC<\/jats:styled-content> curve and the diagnostic accuracy were 0.9247 and 0.8588, respectively. Evidence gathered from studies of moderate quality reveals a high degree of diagnostic accuracy of EBUS\u2010TBNA<\/jats:styled-content> for diagnosing intrathoracic lymph node metastases in patients with extrathoracic malignancies.<\/jats:p>","DOI":"10.1111\/resp.12335","type":"journal-article","created":{"date-parts":[[2014,6,17]],"date-time":"2014-06-17T13:23:37Z","timestamp":1403011417000},"page":"834-841","source":"Crossref","is-referenced-by-count":33,"title":["Endobronchial ultrasound\u2010guided transbronchial needle biopsy for the diagnosis of intrathoracic lymph node metastases from extrathoracic malignancies: A meta\u2010analysis and systematic review"],"prefix":"10.1111","volume":"19","author":[{"given":"Bo","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Oncology General Hospital of Chinese PLA Beijing 100853 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oncology General Hospital of Chinese PLA Beijing 100853 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Oncology General Hospital of Chinese PLA Beijing 100853 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Oncology General Hospital of Chinese PLA Beijing 100853 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengjie","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Oncology General Hospital of Chinese PLA Beijing 100853 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oncology General Hospital of Chinese PLA Beijing 100853 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunchang","family":"Jiao","sequence":"additional","affiliation":[{"name":"Department of Oncology General Hospital of Chinese PLA Beijing 100853 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19870415)59:8<1490::AID-CNCR2820590816>3.0.CO;2-9"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.05.070"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/02841869109092375"},{"issue":"1","key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1159\/000474531","article-title":"Renal cell carcinoma\u2013diagnosis and treatment: state of the art","volume":"31","author":"Bono AV","year":"1997","journal-title":"Eur. 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