{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T14:11:03Z","timestamp":1777558263945,"version":"3.51.4"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,6,17]],"date-time":"2014-06-17T00:00:00Z","timestamp":1402963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Radiotherapy is usually administered to the central airway in patients with unresectable adenoid cystic carcinoma (<jats:styled-content style=\"fixed-case\">ACC<\/jats:styled-content>). The purpose of this study was to describe the outcomes of endobronchial intervention in patients with airway stenosis following radiotherapy for <jats:styled-content style=\"fixed-case\">ACC<\/jats:styled-content>. Moreover, we investigated the incidence and contributing factors for airway stenosis following radiotherapy for <jats:styled-content style=\"fixed-case\">ACC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010seven patients with <jats:styled-content style=\"fixed-case\">ACC<\/jats:styled-content>, who underwent radiotherapy of the tracheobronchial tree from <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>anuary 1995 to <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ecember 2011, were reviewed retrospectively. Fibrotic airway stenoses were diagnosed using three\u2010dimensional computed tomography, flexible bronchoscopy or both.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eleven (23%) of the 47 patients with <jats:styled-content style=\"fixed-case\">ACC<\/jats:styled-content> suffered fibrotic airway stenosis following radiotherapy and received bronchoscopic intervention. The median interval from radiotherapy to diagnosis of fibrotic airway stenosis was 7 months. Low forced expiratory volume in 1\u2009s (<jats:styled-content style=\"fixed-case\">FEV<\/jats:styled-content><jats:sub>1<\/jats:sub>), <jats:styled-content style=\"fixed-case\">FEV<\/jats:styled-content><jats:sub>1<\/jats:sub>\/forced vital capacity and brachytherapy were verified as factors contributing to radiotherapy\u2010induced airway stenosis. Bronchoscopic intervention provided both symptomatic relief and improvement of lung function, and no procedure\u2010related death or major complication was observed. Insertion of a straight silicone stent was required in 10 patients (91%), and 4 (36%) eventually received <jats:styled-content style=\"fixed-case\">Y<\/jats:styled-content>\u2010shaped silicone stents. The stents, once implanted, could not be removed in any of the patients; stents were well\u2010tolerated for a prolonged period in all patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Fibrotic airway stenosis following radiotherapy in patients with <jats:styled-content style=\"fixed-case\">ACC<\/jats:styled-content> is often found. Bronchoscopic intervention, including silicone airway stenting, was a safe and useful method for treating radiotherapy\u2010induced fibrotic airway stenosis in patients with <jats:styled-content style=\"fixed-case\">ACC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12336","type":"journal-article","created":{"date-parts":[[2014,6,17]],"date-time":"2014-06-17T13:23:48Z","timestamp":1403011428000},"page":"914-920","source":"Crossref","is-referenced-by-count":15,"title":["Fibrotic airway stenosis following radiotherapy in patients with adenoid cystic carcinoma"],"prefix":"10.1111","volume":"19","author":[{"given":"Jung Seop","family":"Eom","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BoKyong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hojoong","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyeongman","family":"Jeon","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang\u2010Won","family":"Um","sequence":"additional","affiliation":[{"name":"Division of Pulmonary 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