{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:22:00Z","timestamp":1787016120583,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,7,2]],"date-time":"2014-07-02T00:00:00Z","timestamp":1404259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2014,10]]},"abstract":"Abstract<\/jats:title>\n \n Background and objective<\/jats:title>\n \n The initial peripheral eosinophil count (\n PEC<\/jats:styled-content>\n ) is rarely elevated but tends to increase during the clinical course of acute eosinophilic pneumonia (\n AEP<\/jats:styled-content>\n ). We evaluated whether initial peripheral eosinophilia is an indicator of mild disease in patients with\n AEP<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We retrospectively examined associations between initial peripheral absolute eosinophil count, inflammatory markers and clinical characteristics in 85 patients with\n AEP<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of 85 patients, 24 (28%) had initial peripheral eosinophilia (>500\/\u03bcL). Initial peripheral absolute eosinophil count was inversely correlated to white blood cell (\n WBC<\/jats:styled-content>\n ) count (\u03c1\u2009=\u2009\u22120.386,\n P<\/jats:italic>\n \u2009<\u20090.001), neutrophil percentage (\u03c1\u2009=\u2009\u22120.645,\n P<\/jats:italic>\n \u2009<\u20090.001) and\n C<\/jats:styled-content>\n \u2010reactive protein (\n CRP<\/jats:styled-content>\n ; \u03c1\u2009=\u2009\u22120.495,\n P<\/jats:italic>\n \u2009<\u20090.001). During treatment, peripheral absolute eosinophil counts increased, while inflammatory markers (\n WBC<\/jats:styled-content>\n , neutrophil percentage, and\n CRP<\/jats:styled-content>\n ) decreased. Patients with initial peripheral eosinophilia had a longer duration from onset of symptoms to admission (\n P<\/jats:italic>\n \u2009=\u20090.006), had lower\n WBC<\/jats:styled-content>\n counts, neutrophil percentages and\n CRP<\/jats:styled-content>\n values (all\n P<\/jats:italic>\n \u2009<\u20090.001), and higher oxygen saturation (\n P<\/jats:italic>\n \u2009=\u20090.004) than patients with normal peripheral eosinophil counts. Oxygen requirements (\n P<\/jats:italic>\n \u2009=\u20090.013), duration of oxygen administration (\n P<\/jats:italic>\n \u2009=\u20090.028) and intensive care unit admission rates (\n P<\/jats:italic>\n \u2009=\u20090.003) were lower in patients with initial peripheral eosinophilia. All patients survived and recovered fully after corticosteroid or conservative treatment.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Initial\n PEC<\/jats:styled-content>\n may be related to a milder disease status on admission, compared with normal\n PEC<\/jats:styled-content>\n in patients with\n AEP<\/jats:styled-content>\n . This may help to stratify disease severity in\n AEP<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/resp.12342","type":"journal-article","created":{"date-parts":[[2014,7,2]],"date-time":"2014-07-02T06:22:16Z","timestamp":1404282136000},"page":"1059-1065","source":"Crossref","is-referenced-by-count":32,"title":["Clinical implications of initial peripheral eosinophilia in acute eosinophilic pneumonia"],"prefix":"10.1111","volume":"19","author":[{"given":"Byung Woo","family":"Jhun","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine The Armed Forces Capital Hospital Seong\u2010nam Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine The Armed Forces Capital Hospital Seong\u2010nam Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine The Armed Forces Capital Hospital Seong\u2010nam Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Eun","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine The Armed Forces Capital Hospital Seong\u2010nam Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198908313210903"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/139.1.249"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2112056"},{"key":"e_1_2_6_5_1","first-page":"651","article-title":"Risperidone\u2010induced acute eosinophilic pneumonia","volume":"27","author":"Rizos E","year":"2013","journal-title":"In Vivo"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00221811"},{"key":"e_1_2_6_7_1","first-page":"92","article-title":"Cocaine\u2010induced fatal acute eosinophilic pneumonia: a case report","volume":"106","author":"McCormick M","year":"2007","journal-title":"WMJ"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.12.0555"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.24.2997"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.42.1016"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.39.830"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200206-576OC"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.41.1016"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-2669"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.6.2437"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(96)70206-3"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.165.8.2106110"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2004.00492.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.12-OA-0439"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-2596"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.130.2.371"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00085903"}],"container-title":["Respirology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fresp.12342","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/resp.12342","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T05:31:31Z","timestamp":1696138291000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/resp.12342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,2]]},"references-count":21,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1111\/resp.12342"],"URL":"https:\/\/doi.org\/10.1111\/resp.12342","archive":["Portico"],"relation":{},"ISSN":["1323-7799","1440-1843"],"issn-type":[{"value":"1323-7799","type":"print"},{"value":"1440-1843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,2]]}}}