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This review will focus on diagnostic and prognostic information provided by lung function tests in the idiopathic interstitial pneumonias, particularly idiopathic pulmonary fibrosis and non\u2010specific interstitial pneumonia. These disorders are characterized by small stiff lungs with impaired gas exchange. Lung function tests, particularly lung volumes and gas transfer, used initially on patient presentation and then repeatedly on follow up, together with high\u2010resolution computed tomography scans, can generate predictive formulae which are superior to single tests and can be used to provide useful information to assess the natural history of the disease or guide therapy. The concomitant presence of emphysema may mask the degree of restriction and may have adverse prognostic implications when accompanied by pulmonary hypertension.<\/jats:p>","DOI":"10.1111\/resp.12348","type":"journal-article","created":{"date-parts":[[2014,7,15]],"date-time":"2014-07-15T16:51:53Z","timestamp":1405443113000},"page":"952-959","source":"Crossref","is-referenced-by-count":26,"title":["Respiratory disease and respiratory physiology: Putting lung function into perspective interstitial lung disease"],"prefix":"10.1111","volume":"19","author":[{"given":"Norbert","family":"Berend","sequence":"first","affiliation":[{"name":"The George Institute for Global Health Woolcock Institute for Medical Research University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,14]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201308-1483ST"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200702-254OC"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.155.1.9001319"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.062836"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.182.2.1732946"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2462070712"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.129.3.746"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2010.01778.x"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-2306"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00021005"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-142-12_Part_1-200506210-00005"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200703-463PP"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.173.4.10511155"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.140574"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2323031059"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00035205"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-1885"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000235722"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0007-0971(76)90027-9"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1979.47.4.683"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00176190"},{"key":"e_1_2_12_23_1","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1152\/jappl.1994.76.2.731","article-title":"Structure and function in fibrosing alveolitis","volume":"76","author":"Verbeken EK","year":"1994","journal-title":"J. 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