{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T06:41:32Z","timestamp":1696056092335},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,7,23]],"date-time":"2014-07-23T00:00:00Z","timestamp":1406073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2014,11]]},"abstract":"Abstract<\/jats:title>Background and objective<\/jats:title>Reduced atmospheric pressure during air travel can cause significant hypoxaemia in some patients with respiratory disease. Our aims were to investigate the degree of hypoxaemia in patients with obesity hypoventilation syndrome (OHS<\/jats:styled-content>) during hypoxic challenge test (HCT<\/jats:styled-content>), and to identify any predictors of a positive HCT<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>Thirteen patients underwent assessment, including HCT<\/jats:styled-content>, lung function and incremental shuttle walk test. All had OHS<\/jats:styled-content> well controlled with long\u2010term nocturnal non\u2010invasive ventilation (NIV<\/jats:styled-content>). Patients with chronic obstructive pulmonary disease were excluded. A positive HCT<\/jats:styled-content> was defined according to the B<\/jats:styled-content>ritish Thoracic Society (BTS<\/jats:styled-content>) recommendation as arterial oxygen tension (PaO2<\/jats:sub><\/jats:styled-content>)\u2009<6.6\u2009kPa and\/or oxygen saturation\u2009<85%.<\/jats:p><\/jats:sec>Results<\/jats:title>Mean age was 57 (\u00b1\u200911) years. Mean body mass index was 51.7 (\u00b1\u200912)\u2009kg\/m2<\/jats:sup>. Mean baseline PaO2<\/jats:sub><\/jats:styled-content> and arterial carbon dioxide tension (PaCO2<\/jats:sub><\/jats:styled-content>) were 10.2 (9.5\u201311.3) kPa and 5.2 (3.7\u20136.8) kPa, respectively. Seven patients (54%) had a positive HCT<\/jats:styled-content>. The correlation between baseline PaO2<\/jats:sub><\/jats:styled-content> and PaO2<\/jats:sub><\/jats:styled-content> at the end of the HCT was not statistically significant (r<\/jats:italic>\u2009=\u20090.433, P<\/jats:italic>\u2009=\u20090.184). A negative correlation was observed between baseline PaCO2<\/jats:sub><\/jats:styled-content> and PaO2<\/jats:sub><\/jats:styled-content> at the end of the HCT<\/jats:styled-content> (r<\/jats:italic>\u2009=\u2009\u22120.793, P<\/jats:italic>\u2009=\u20090.004). A positive correlation was observed between the distance walked and the PaO2<\/jats:sub><\/jats:styled-content> at the end of the HCT<\/jats:styled-content> (r<\/jats:italic>\u2009=\u20090.608, P<\/jats:italic>\u2009=\u20090.047).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>OHS is a risk factor for severe hypoxaemia during air travel even if the ventilatory failure is well controlled. An HCT<\/jats:styled-content> before air travel is advisable in all OHS<\/jats:styled-content> patients. Those with positive HCT<\/jats:styled-content> may use NIV<\/jats:styled-content> or have oxygen on\u2010board as per BTS<\/jats:styled-content> recommendation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12353","type":"journal-article","created":{"date-parts":[[2014,7,24]],"date-time":"2014-07-24T00:57:05Z","timestamp":1406163425000},"page":"1229-1232","source":"Crossref","is-referenced-by-count":4,"title":["Pre\u2010flight assessment in patients with obesity hypoventilation syndrome"],"prefix":"10.1111","volume":"19","author":[{"given":"Masood","family":"Ali","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Southend University Hospital NHS Foundation Trust UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian E.","family":"Smith","sequence":"additional","affiliation":[{"name":"Respiratory Support and Sleep Centre Papworth Hospital NHS Foundation Trust Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atul","family":"Gulati","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Colchester Hospital University Foundation Trust Colchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Shneerson","sequence":"additional","affiliation":[{"name":"Respiratory Support and Sleep Centre Papworth Hospital NHS Foundation Trust Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,7,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3357\/ASEM.2272.2008"},{"key":"e_1_2_6_3_1","first-page":"5,II","article-title":"Medical guidelines for airline travel, 2nd ed","volume":"74","author":"Aerospace Medical Association, Medical Guidelines Task Force","year":"2003","journal-title":"Aviat. 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