{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T06:24:32Z","timestamp":1770963872783,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,8,14]],"date-time":"2014-08-14T00:00:00Z","timestamp":1407974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Green Lane Research and Education Fund"},{"name":"Myrtle Martin Trust"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and objectives<\/jats:title><jats:p>Dyspnoea is a common symptom in sarcoidosis and is not predictably related to pulmonary function or radiology. A subjective symptom of dyspnoea is likely to be influenced by patient perception and experience. The aim of this study was to determine the prevalence and nature of dyspnoea in sarcoidosis and describe the relationship of dyspnoea to psychological factors and health\u2010related quality of life (<jats:styled-content style=\"fixed-case\">HRQL<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010six subjects (31 men, mean age 51 years) with sarcoidosis completed an <jats:styled-content style=\"fixed-case\">HRQL<\/jats:styled-content> measure, <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>t <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>eorge's <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>espiratory <jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>uestionnaire (<jats:styled-content style=\"fixed-case\">SGRQ<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ospital <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>nxiety and <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>epression <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>cale (<jats:styled-content style=\"fixed-case\">HADS<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ijmegen questionnaire. The presence of symptoms of dyspnoea was noted and qualitative descriptors for dyspnoea were chosen at peak exercise. Resting pulmonary function was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010four per cent of the subjects reported dyspnoea. Those with symptoms were older, had a longer duration of disease and with lower forced expiratory volume in 1\u2009s (<jats:styled-content style=\"fixed-case\">FEV<jats:sub>1<\/jats:sub><\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">FEV<jats:sub>1<\/jats:sub><\/jats:styled-content>\/forced vital capacity (<jats:styled-content style=\"fixed-case\">FVC<\/jats:styled-content>) (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Symptoms of dyspnoea were associated with worse <jats:styled-content style=\"fixed-case\">HRQL<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.005) and higher scores on the <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ijmegen questionnaire (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Anxiety was not associated with dyspnoea and only a trend to greater depression was observed (<jats:italic>P<\/jats:italic>\u2009=\u20090.066). In multivariate analysis, <jats:styled-content style=\"fixed-case\">SGRQ<\/jats:styled-content> and Nijmegen scores predicted dyspnoea independent of demographic factors and resting pulmonary function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Dyspnoea is common in sarcoidosis and is associated with worse <jats:styled-content style=\"fixed-case\">HRQL<\/jats:styled-content> irrespective of baseline pulmonary function. Hyperventilation appears to be a factor contributing to dyspnoea and the <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ijmegen questionnaire may be helpful in assessing dyspnoea and hyperventilation in sarcoidosis patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12359","type":"journal-article","created":{"date-parts":[[2014,8,14]],"date-time":"2014-08-14T06:18:54Z","timestamp":1407997134000},"page":"1019-1024","source":"Crossref","is-referenced-by-count":23,"title":["The relationships among dyspnoea, health\u2010related quality of life and psychological factors in sarcoidosis"],"prefix":"10.1111","volume":"19","author":[{"given":"Sally","family":"de Boer","sequence":"first","affiliation":[{"name":"Green Lane Respiratory Services Auckland City Hospital Auckland District Health Board  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Kolbe","sequence":"additional","affiliation":[{"name":"Green Lane Respiratory Services Auckland City Hospital Auckland District Health Board  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret L.","family":"Wilsher","sequence":"additional","affiliation":[{"name":"Green Lane Respiratory Services Auckland City Hospital Auckland District Health Board  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,8,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0954-6111(98)90007-5"},{"key":"e_1_2_7_3_1","first-page":"183","article-title":"Quality of life in sarcoidosis: a comparison between members of a patient organisation and a random sample","volume":"15","author":"De Vries J","year":"1998","journal-title":"Sarcoidosis Vasc. 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